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![Invitrogen™ Human ABL1 [F317L], GST Tag Recombinant Protein 10 μg](https://assets.fishersci.com/TFS-Assets/LSG/product-images/Cell_Bio_Rec_Prot_Invitrogen_Vial.jpg-650.jpg)
Invitrogen™ Human ABL1 [F317L], GST Tag Recombinant Protein
This ABL1 F317L Recombinant Human Protein (27-end) was expressed in insect cells.
Marque: Invitrogen™ A33475
Informations supplémentaires : Poids : 0.10000kg
Description
- This ABL1 F317L recombinant human protein (27–end) was expressed in insect cells
- ABL1 cytoplasmic tyrosine kinase protooncogene encodes a cytoplasmic and nuclear kinase that has been implicated in processes of cell differentiation, cell division, cell adhesion, and stress response
- Activity of ABL protein is negatively regulated by its SH3 domain and deletion of the SH3 domain turns ABL1 into an oncogene
- Translocation and head-to-tail fusion of the BCR and ABL1 genes is present in many cases of chronic myelogeneous leukemia
- The DNA-binding activity of the ubiquitously expressed ABL1 tyrosine kinase is regulated by CDK1-mediated phosphorylation, suggesting a cell cycle function for ABL1
- ABL1 F317L recombinant human protein is also available in our SelectScreen™ Kinase Profiling Service
- Validated for use with the Z'-LYTE™ assay
- Available in multiple pack sizes for convenient use
Spécification
| NP_005148.2 | |
| 146.3 kDa | |
| ABL Kinase Family | |
| Human | |
| GST Tag | |
| Dry Ice | |
| Kinases & Inhibitors | |
| Liquid |
| Kinase Assay | |
| 10 μg | |
| aa 27 - end | |
| Recombinant | |
| Storage Buffer: 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 10 mM glutathione, 0.1 mM EDTA, 0.25 mM DTT, 0.1 mM PMSF, 25% glycerol. | |
| Baculovirus | |
| Recombinant, Active, Mutant |