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ACROBiosystems ActiveMax™ Human Oncostatin M (OSM) Protein, Tag Free
266.13€ - 1838.68€
Spécification
Numéro d’adhésion | NP_065391.1 |
---|---|
Poids moléculaire | 25.8 kDa |
Source | ActiveMax™ Human Oncostatin M, Tag Free (OSM-H5213) is expressed from human 293 cells (HEK293). It contains AA Ala 26 - Arg 252 (Accession # NP_065391.1). |
Immunogène | Ala 26 - Arg 252 |
Conditions de stockage | -20°C |
Code produit | Marque | Quantité | Prix | Quantité et disponibilité | |||||
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Code produit | Marque | Quantité | Prix | Quantité et disponibilité | |||||
16487929
|
ACROBiosystems
OSM-H5213-1MG |
1 mg |
1838.68€
1mg |
Expédition estimée: 30-04-2024 Connectez-vous pour voir le stock disponible |
Veuillez vous connecter pour pouvoir commander cet article. Besoin d'un compte web? Créer le vôtre dès maintenant! | ||||
15867387
|
ACROBiosystems
OSM-H5213-50UG |
50 μg |
266.13€
50µg |
Expédition estimée: 30-04-2024 Connectez-vous pour voir le stock disponible |
Veuillez vous connecter pour pouvoir commander cet article. Besoin d'un compte web? Créer le vôtre dès maintenant! | ||||
Description
Oncostatin M is also known as OSM, is a glycoprotein belonging to the interleukin-6 family of cytokines that has functions mainly in cell growth. Of these cytokines it most closely resembles leukemia inhibitory factor (LIF) in both structure and function. However, it is as yet poorly defined and is proving important in liver development, haematopoeisis, inflammation and possibly CNS development. It is also associated with bone formation and destruction. OSM signals through cell surface receptors that contain the protein gp130. The type I receptor is composed of gp130 and LIFR, the type II receptor is composed of gp130 and OSMR. Oncostatin M (OSM) was previoustly identified by its ability to inhibit the growth of cells from melanoma and other solid tumors. It also has been reported that OSM, like LIF, IL-6 and G-CSF, has the ability to inhibit the proliferation of murine M1 myeloid leukemic cells and can induce their differentiation into macrophage-like cells. The human form of OSM is insensitive between pH2 and 11 and resistant to heating for one hour at 56 degree but is not stable at 90 degrees. The three dimensional structure of human OSM has been solved to atomic resolution, confirming the predicted long chain four helix bundle topology. Comparing this structure with the known structures of other known LC cytokines shows it to be most closely related to LIF.
This protein carries no "e;tag"e;. The protein has a calculated MW of 25.8 kDa. The protein migrates as 36 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.Spécification
NP_065391.1 | |
ActiveMax™ Human Oncostatin M, Tag Free (OSM-H5213) is expressed from human 293 cells (HEK293). It contains AA Ala 26 - Arg 252 (Accession # NP_065391.1). | |
-20°C | |
Oncostatin M | |
Human | |
PBS, pH7.4 | |
HEK293 | |
ActiveMax™ Cytokines |
25.8 kDa | |
Ala 26 - Arg 252 | |
OSM,MGC20461,Oncostatin M | |
Unconjugated | |
Tag Free | |
Less than 1.0 EU / μg by the LAL method. | |
Powder | |
>95% as determined by SDS-PAGE |