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ACVR1B Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Marque:  Proteintech 10086-1-AP-150UL

Informations supplémentaires : Poids : 0.00010kg

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Code produit. 16806243

  • 399.00€ / 150µL
Expédition estimée: 12-04-2024
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Description

Description

Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with a cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling, and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. This gene encodes activin A type IB receptor, composed of 11 exons. Alternative splicing and alternative polyadenylation result in 3 fully described transcript variants. The mRNA expression of variants 1, 2, and 3 is confirmed, and a potential fourth variant contains an alternative exon 8 and lacks exons 9 through 11, but its mRNA expression has not been confirmed.
Spécification

Spécification

ACVR1B
Polyclonal
Unconjugated
ACVR1B
activin A receptor, type IB, Activin receptor like kinase 4, Activin receptor type 1B, Activin receptor type IB, ACTR IB, ACTRIB, ACVR1B, ACVRLK4, ALK 4, ALK4, SKR2
Rabbit
Antigen Affinity Chromatography
RUO
11479, 29381, 91
-20°C
Liquid
Western Blot
0.33 mg/mL
PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
P36896, P80202, Q61271
ACVR1B
ACVR1B Fusion Protein Ag0129
150 μL
Primary
Human, Mouse, Rat
Antibody
IgG
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