CD11b Rat anti-Mouse, APC-Cy7, Clone: M1/70, BD
Rat Monoclonal Antibody
Marque: BD Biosciences 561039
Informations supplémentaires : Poids : 0.01000kg
The M1/70 antibody reacts with the 170kDa α[M] chain of Mac-1 (CD11b/CD18, α[M]β integrin), also known as complement receptor 3 (CR3), which mediates adhesion to C3bi and ICAM-1 (CD54). Mac-1 is expressed at varying levels on granulocytes, macrophages, myeloid-derived dendritic cells, natural killer cells, microglia, and B-1 cells. Mac-1 expression is rapidly up-regulated on neutrophils after activation, in the same time period that CD62L (L-selectin) is shed from the cell surface. M1/70 antibody reportedly blocks cell adherence and C3bi binding, but it does not block cell-mediated lysis. Cross-reaction of mAb M1/70 with CD11b on human monocytes, polymorphonuclear leukocytes, and NK cells has been reported. This antibody is routinely tested by flow cytometric analysis (≤0.25 μg/million cells).
Host Species: Rat
Isotype: IgG2b, κ
Species Reactivity: Mouse
Immunogen: Mouse splenic Cells
|Aqueous buffered solution containing ≤0.09% sodium azide.|
|Itgam; Integrin alpha-M; Ly-40; Mac-1a; Mac-1 alpha; CR3A; CR-3 alpha chain|
|Mouse Splenic Cells|
|Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.|
For Research Use Only.