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CD163 Mouse anti-Human, PE, Clone: GHI/61, BD

Mouse Monoclonal Antibody

Marque:  BD Biosciences 560933

Informations supplémentaires : Poids : 0.01000kg

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Code produit. 15870609

  • 135.66€ / 1 pièce
Date d’expédition estimée: 23-12-2021

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Description

Description

The GHI/61 monoclonal antibody specifically binds to human CD163. CD163 is also known as Scavenger receptor cysteine-rich type 1 protein M130 (M130), Hemoglobin scavenger receptor and Macrophage-associated antigen. CD163 is a 110-130 kDa transmembrane glycoprotein. CD163 is a monocyte/macrophage-restricted antigen expressed on the majority of tissue macrophages and peripheral blood monocytes. CD163 belongs to the scavenger receptor superfamily. Its expression on monocytes is upregulated upon cellular activation. CD163 expression reportedly changes on monocytes and macrophages as these cells differentiate. This finding suggests a role for this molecule in the differentiation and/or regulation of monocyte and macrophage function. CD163 may play a role in the clearance and endocytosis of hemoglobin and haptoglobin complexes by macrophages.

It has been reported (Maniecki et al., 2011) that the presence of calcium impacts the binding affinity of clone GHI/61 to CD163. There is a variation in detecting CD163 positive monocytes when the cells are prepared with different anticoagulants, where heparin was observed to have the highest inhibitory effect on clone GHI/61.

Spécification

Spécification

CD163
GHI/61
Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
Mouse
25 Tests
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Monoclonal
Flow Cytometry
PE
Affinity Purified
IgG1, κ
RUO
Primary
Human
Vidéos
FDS
Documents
Certificats
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For Research Use Only.