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CD183 Mouse anti-Human, Unlabeled, Clone: 1C6/CXCR3, BD

Mouse Monoclonal Antibody

Marque:  BD Biosciences 557184

Informations supplémentaires : Poids : 0.01000kg

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Code produit. 15868848

  • 525.00€ / 1 pièce
Date d’expédition estimée: 17-12-2021

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Description

Description

Clone 1C6/CXCR3 reacts with the human form of the 40 - 41kDa seven-transmembrane protein and member of the G protein-coupled receptor family. CXCR3 is expressed primarily on activated T cells that infiltrate inflammatory sites. It has also been detected on some circulating T cells, B cells, and NK cells. Reports show that some CXCR3 T cells also express CCR5 and are mostly CD45RO cells. Three ligands for CXCR3 have been identified. They are interferon-γ inducible 10kDa protein (IP-10), monokine induced by interferon-γ (MIg), and interferon-inducible T-cell γ chemoattractant (I-TAC). These chemokines are produced by a variety of cells upon stimulation by IFN γ and interact with CXCR3 to mediate T-cell chemotaxis. This reagent has been reported to be suitable for immunohistochemical staining of acetone-fixed, frozen sections and/or formalin-fixed, paraffin-embedded tissue sections with citrate pretreatment. Clone CXCR3 also cross reacts with a subset of peripheral blood lymphocytes of baboon, and both rhesus and cynomolgus macaque monkeys. The distribution of lymphocytes is similar to that observed with peripheral blood lymphocytes from normal human donors. CXCR3 has been clustered as CD183 in the VIIth HLDA workshop. This product is routinely tested by flow cytometric analysis. Other applications were tested at BD Biosciences Pharmingen during antibody development only or reported in the literature.

Host Species: Mouse
Clone: 1C6/CXR3
Isotype: IgG1 κ
Species Reactivity: Human

Flow Cytometry, Functional Assay

Spécification

Spécification

CD183
1C6/CXCR3
Unconjugated
No azide/low endotoxin: Aqueous buffered solution containing no preservative, 0.2μm sterile filtered. Endotoxin level is ≤0.01 EU/μg (≤0.001 ng/μg) of protein as determined by the LAL assay.
Mouse
IgG1, κ
RUO
Store undiluted at 4°C
Monoclonal
Flow Cytometry
1.0mg/mL
CXCR3; C-X-C chemokine receptor type 3; GPR9; IP10R; MigR; CKRL2; CMKAR3
Affinity Purified
Human CXCR3 Peptide
0.5mg
Immunology
Primary
Human
Vidéos
FDS
Documents
Certificats
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For Research Use Only.