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CD221 Mouse anti-Human, PE, Clone: 1H7, BD

Mouse Monoclonal Antibody

Marque:  BD Biosciences 555999

Informations supplémentaires : Poids : 0.02000kg

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Code produit. 15858578

  • 426.36€ / 1 pièce
Expédition estimée: 22-02-2023
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Description

Description

The 1H7 monoclonal antibody specifically binds to the α subunit of the human insulin-like growth factor-I (IGF-I) receptor that is also known as CD221. CD221 is a receptor tyrosine kinase that has high affinity for IGF-1 and low affinity for insulin and IGF-2. CD221 is synthesized as a 180 kDa precursor molecule that is processed into two subunits, a 135 kDa α subunit which is disulfide-linked to a 90 kDa β subunit. The mature IGF-IR complex is comprised of two extracellular α subunits and two transmembrane β subunits that each possesses a tyrosine kinase domain. When bound by ligand, the IGF-1 receptor autophosphorylates multiple tyrosine sites in its β chains and phosphorylates other signaling molecules that regulate cell growth, development, and neoplastic transformation. CD221 is structurally and functionally similar to the insulin receptor (aka, CD220) and is expressed on a variety of human hematopoietic and non-hematopoietic cells. The 1H7 antibody does not crossreact with the human insulin receptor and can block IGF-I- or IGF-II-stimulated cell growth.

Spécification

Spécification

CD221
Monoclonal
PE
Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
Purified Human Placental IGF-I Receptor
100 Tests
Immunology
Human
IgG1 κ
Flow Cytometry
1H7
IGF1R; IGF-I receptor; IGFIR; IGFR; Insulin-like growth factor 1 receptor
Mouse
Affinity Purified
RUO
Primary
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
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For Research Use Only.