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CD279 Hamster anti-Mouse, PE, Clone: J43, BD

Hamster Monoclonal Antibody

Marque:  BD Biosciences 551892

Informations supplémentaires : Poids : 0.01000kg

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Código de producto. 15866728

  • 571.20€ / 1 pièce
Date d’expédition estimée: 24-12-2021

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Descripción

Descripción

The J43 antibody reacts with CD279 (PD-1), a 50-55-kDa glycoprotein encoded by the Pdcd1 gene of the CD28 family of the Ig superfamily. The expression of Pdcd1 mRNA and PD-1 protein is tightly regulated. PD-1 is transiently expressed on CD4-CD8thymocytes, it is upregulated on some cell lines upon induction of apoptosis, it is induced on thymocytes and splenic T and B lymphocytes after stimulation through their antigen receptors, and it is induced on activated myeloid cells. In addition, Pdcd1 mRNA is transiently expressed in developing B lymphocytes at the pro-B-cell stage. The presence of an ITIM (Immunoreceptor nhibitory Motif) on PD-1's intracytoplasmic region and the development of splenomegaly and breakdown of peripheral tolerance in PD-1[-/-] mice suggest that PD-1 may be involved in the negative regulation of immune responses. The PD-1 ligands, B7-H1 (also known as PD-L1) and B7-DC (PD-L2), are members of the B7 family of the Ig superfamily. The J43 antibody blocks the binding of PD-1 to its two ligands.

Especificaciones

Especificaciones

CD279
J43
PE
Aqueous buffered solution containing ≤0.09% sodium azide.
Hamster
IgG2, κ
RUO
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Monoclonal
Flow Cytometry
0.2mg/mL
PD-1
Affinity Purified
Syrian Hamster kidney cell line BKH transfected with Pdcd1 cDNA
0.1mg
Immunology
Primary
Murine
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SDS
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Product Certifications
Ofertas especiales

Ofertas especiales

For Research Use Only.