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CD8 Mouse anti-Human, Brilliant Violet 421, Clone: RPA-T8, BD
Mouse Monoclonal Antibody
298.00€ - 805.00€
Spécification
Antigène | CD8 |
---|---|
Clone | RPA-T8 |
Applications | Flow Cytometry |
Classification | Monoclonal |
Conjugué | Brilliant Violet 421 |
Code produit | Marque | Quantité | Prix | Quantité et disponibilité | |||||
---|---|---|---|---|---|---|---|---|---|
Code produit | Marque | Quantité | Prix | Quantité et disponibilité | |||||
15871909
|
BD Biosciences
562429 |
25 Tests |
298.00€
1 pièce |
Expédition estimée: 16-05-2024 Connectez-vous pour voir le stock disponible |
Veuillez vous connecter pour pouvoir commander cet article. Besoin d'un compte web? Créer le vôtre dès maintenant! | ||||
15861909
|
BD Biosciences
562428 |
100 Tests |
805.00€
1 pièce |
Expédition estimée: 16-05-2024 Connectez-vous pour voir le stock disponible |
Veuillez vous connecter pour pouvoir commander cet article. Besoin d'un compte web? Créer le vôtre dès maintenant! | ||||
Description
The RPA-T8 monoclonal antibody specifically binds to CD8 alpha (CD8α). CD8α is a type I transmembrane glycoprotein and a member of the immunoglobulin superfamily. CD8α is expressed by the majority of thymocytes, by subpopulations of αβ T cells and γδ T cells and by some NK cells. Cell surface CD8α is expressed either as a disulfide-linked homodimer (CD8αα) or as a heterodimer (CD8αβ) when disulfide-bonded to a CD8 beta chain (CD8β). CD8-positive αβ T cells coexpress both CD8αα homodimers and CD8αβ heterodimers whereas some γδ T cells and NK cells express CD8αα homodimers. CD8 plays important roles in T cell activation and selection. The extracellular IgSF domain of CD8α binds to a non-polymorphic determinant on HLA class I molecules (α3 domain) and enables CD8 to function as a co-receptor with MHC class I-restricted TCR during T cell recognition of antigen. The cytoplasmic domain of CD8α associates with Lck, a Src family protein tyrosine kinase that is involved in intracellular signaling. The RPA-T8 and HIT8a (Cat. No. 555337) monoclonal antibodies are not cross-blocking. The antibody was conjugated to Brilliant Violet 421 and has been developed in collaboration with Sirigen. With an Ex Max of 407-nm and Em Max at 421-nm, Brilliant Violet 421 can be excited by the violet laser and detected in the standard Pacific Blue filter set (eg, 450/50-nm filter). Brilliant Violet 421 conjugates are very bright, often exhibiting a 10 fold improvement in brightness compared to Pacific Blue conjugates.
Host Species: Mouse
Clone: RPA-T8
Isotype: IgG1, κ
Species Reactivity: Human
Flow Cytometry
Spécification
CD8 | |
Flow Cytometry | |
Brilliant Violet 421 | |
RUO | |
Aqueous buffered solution containing BSA and ≤0.09% sodium azide. | |
IgG1 κ | |
Affinity Purified | |
CD8α; CD8A; CD8 alpha; Leu2; MAL; T8; p32 |
RPA-T8 | |
Monoclonal | |
Mouse | |
Baboon, Cynomolgus, Human, Rhesus Monkey | |
Human CD8a | |
Primary | |
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze. |
For Research Use Only.