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Cyclin A Mouse anti-Human, Unlabeled, Clone: BF683, BD

Mouse Monoclonal Antibody

Marque:  BD Biosciences 554174

Informations supplémentaires : Poids : 0.01000kg

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Code produit. 15867598

  • 275.00€ / 1 pièce
Date d’expédition estimée: 17-12-2021

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Description

Description

Cyclins and cyclin-dependent kinases (cdks) are evolutionarily conserved proteins that are essential for cell-cycle control in eukaryotes. Cyclins (regulatory subunits) bind to cdks (catalytic subunits) to form complexes that regulate the progression of the cell cycle. The main cyclin-cdks complexes formed in vertebrate cells are cyclin D-cdk4 (G0/G1), cyclin E-cdk2 (G1/S), cyclin A-cdk2 (S) and cyclin B1-cdk1 (G2/M). These complexes are regulated by activating and inhibitory phosphorylation events, as well as by interactions with small regulatory proteins including p21 and p27Kip1. Specific substrates for cdk-cyclin complexes include nuclear lamins, histones, oncogenes (e.g., c-abl and SV40 large T-Ag), tumor suppressor genes (e.g., retinoblastoma protein, Rb), nucleolin and others. Cyclin A is involved in both S-phase and G2/M transitions of the cell cycle through its association with cdk2 and cdk1, respectively. Cyclin A may also form a complex with the adenovirus oncoprotein E1A which has DNA binding activity. Human cyclin A has been reported to migrate between 54-60kDa by SDS-PAGE and clone BF683 reportedly does not cross-react with mouse, rat or mink cyclin A.

Host Species: Mouse
Clone: BF683
Isotype: IgE
Species Reactivity: Human
Immunogen: Human Cyclin A Recombinant Protein
Formula Weight [Chemical]: 54-60kDa

Flow Cytometry, Immunoprecipitation, Western Blotting

Spécification

Spécification

Cyclin A
BF683
Unconjugated
Affinity Purified
Human Cyclin A Recombinant Protein
0.1mg
Cell Biology
Primary
Human
Western Blot
0.5mg/mL
Aqueous buffered solution containing ≤0.09% sodium azide.
Mouse
IgE
RUO
Store undiluted at 4°C
Monoclonal
Vidéos
FDS
Documents
Certificats
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For Research Use Only.