Cyclin A Mouse anti-Human, Unlabeled, Clone: BF683, BD
Mouse Monoclonal Antibody
Marque: BD Biosciences 554175
Informations supplémentaires : Poids : 0.01000kg
Cyclins and cyclin-dependent kinases (cdks) are evolutionarily conserved proteins that are essential for cell-cycle control in eukaryotes. Cyclins (regulatory subunits) bind to cdks (catalytic subunits) to form complexes that regulate the progression of the cell cycle. The main cyclin-cdks complexes formed in vertebrate cells are cyclin D-cdk4 (G0/G1), cyclin E-cdk2 (G1/S), cyclin A-cdk2 (S) and cyclin B1-cdk1 (G2/M). These complexes are regulated by activating and inhibitory phosphorylation events, as well as by interactions with small regulatory proteins including p21 and p27Kip1. Specific substrates for cdk-cyclin complexes include nuclear lamins, histones, oncogenes (e.g., c-abl and SV40 large T-Ag), tumor suppressor genes (e.g., retinoblastoma protein, Rb), nucleolin and others. Cyclin A is involved in both S-phase and G2/M transitions of the cell cycle through its association with cdk2 and cdk1, respectively. Cyclin A may also form a complex with the adenovirus oncoprotein E1A which has DNA binding activity. Human cyclin A has been reported to migrate between 54-60kDa by SDS-PAGE and clone BF683 reportedly does not cross-react with mouse, rat or mink cyclin A.
Host Species: Mouse
Species Reactivity: Human
Immunogen: Human Cyclin A Recombinant Protein
Formula Weight [Chemical]: 54-60kDa
Flow Cytometry, Immunoprecipitation, Western Blotting
|Human Cyclin A Recombinant Protein|
|Aqueous buffered solution containing ≤0.09% sodium azide.|
|Store undiluted at 4°C|
For Research Use Only.