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Hsp75/TRAP1 Mouse, Unlabeled, Clone: 42, BD

Mouse Monoclonal Antibody

314.00€ - 550.00€

Spécification

Antigène Hsp75/TRAP1
Clone 42
Concentration 250μg/mL
Applications Western Blot
Classification Monoclonal
Consulter d'autres spécifications

Produits 2
Code produit Marque Quantité Prix Quantité et disponibilité  
Code produit Marque Quantité Prix Quantité et disponibilité  
15866169
Afficher les documents Détails de la promotion
BD Biosciences
612344
50 μg
314.00€
1 pièce
Voir les produits de remplacement
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»
Expédition estimée: 22-04-2024
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15876169
Afficher les documents Détails de la promotion
BD Biosciences
612345
150 μg
550.00€
1 pièce
Voir les produits de remplacement
Économisez jusqu'à 
»
Expédition estimée: 22-04-2024
pour voir le stock disponible 
Veuillez vous pour pouvoir commander cet article. Besoin d'un compte web? Créer le vôtre dès maintenant!
Description

Description

The hsp90 family of molecular chaperones is involved in a number of signal transduction pathways, including cell division, protein folding and transport. A new member of this family was recently identified as TRAP1 (Tumor necrosis factor receptor-associated protein) or hsp75. TRAP1 is a mitochondrial protein that is an ATPase and ATP-binding protein, rendering it similar to hsp90. There is a high degree of homology between TRAP1 and hsp90 in 6 domains, however one major difference is that a highly charged domain present in hsp90 is absent in TRAP1. TRAP1 has been shown to interact with the intracellular domain of the type 1 receptor for tumor necrosis factor (TNFR-1IC) and to the retinoblastoma protein (Rb). Signaling through TNFR-1 induces antiviral responses, fibroblast proliferation, cytotoxicity, etc. TRAP1 binds TNFR-1IC outside of the death domain leading to disruption in the signaling by TNFR-1. Rb has been shown to play a pivotal role in cellular differentiation and progression through the cell cycle. TRAP1 associates with Rb via an LxCxE motif, which is common among proteins that interact with Rb through SV40 T-antigen binding domain. Thus, TRAP1 is a new member of the hsp90 family that interacts with Rb and TNFR-1IC.

Immunofluorescence, Western Blotting

Spécification

Spécification

Hsp75/TRAP1
250μg/mL
Monoclonal
Mouse
Cell Biology
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
IgG1
Affinity Purified
TRAP1
42
Western Blot
Unconjugated
RUO
Canine, Human, Mouse, Rat
Human Hsp75/TRAP1 aa. 253-464
Primary
Store undiluted at -20°C.
Vidéos
FDS
Documents

Documents

Product Certifications

For Research Use Only.