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MAD2 Mouse, Unlabeled, Clone: 48, BD

Mouse Monoclonal Antibody

Marque:  BD Biosciences 610679

Informations supplémentaires : Poids : 0.01000kg

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Code produit. 15875579

  • 540.60€ / 1 kit
Date d’expédition estimée: 29-12-2021

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Description

Description

Progression of the mammalian cell cycle is regulated by phosphorylation/dephosphorylation and synthesis/degradation of many key proteins. These events are of utmost importance at the checkpoints, or transition points, of the cell cycle. MAD2 (Mitotic Arrest Deficient) is the human homolog of a yeast and Xenopus protein that is essential for spindle assembly during mitosis. The human hsMAD2 gene encodes a protein of 205 amino acids with a predicted molecular weight of 23.5 kDa. Binding of affinity purified polyclonal antibodies to the MAD2 protein prevents mitosis of HeLa cells. This indicates that, like its invertebrate relatives, MAD2 is necessary for mitosis. Furthermore, MAD2 is localized at the kinetochore of condensed chromosomes during mitosis and cells defective in the mitotic checkpoint have reduced levels of MAD2.

Spécification

Spécification

MAD2
48
Unconjugated
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Mouse
IgG2a
RUO
Store undiluted at -20°C.
Monoclonal
Western Blot
250μg/mL
Mitotic Arrest Deficient-2
Affinity Purified
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
150μg
Cell Biology
Primary
Human, Murine, Rat
Vidéos
FDS
Documents
Certificats
Promotions

Promotions

For Research Use Only.