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MEK2 Mouse, Unlabeled, Clone: 96/MEK2, BD
Mouse Monoclonal Antibody
321.00€
Specifications
| Antigène | MEK2 |
|---|---|
| Clone | 96/MEK2 |
| Concentration | 250μg/mL |
| Applications | Western Blot |
| Classification | Monoclonal |
| Product Code | Brand | Quantité | Price | Quantity & Availability | |||||
|---|---|---|---|---|---|---|---|---|---|
| Product Code | Brand | Quantité | Price | Quantity & Availability | |||||
|
15865349
|
BD Biosciences
610235 |
50 μg |
Cet article est actuellement indisponible ou discontinu.
Veuillez consulter la page produit pour de possible alternative dans l’onglet |
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Description
MEK (Map/Erk Kinase) 1 and 2 are serine/threonine kinases, also known as MAP kinase kinases (MAP2K1 and 2, MAPKK1 and 2, or MKK1 and 2). They activate the MAP (Activated Protein) kinases, also known as ERKs (Extracellular signal Regulated Kinases), which are critical kinases in multiple signal transduction pathways that regulate cell growth and differentiation. Activation of MEK 1 and 2 is dependent upon phosphorylation of serines 218 and/or 222 by activated MAP kinase kinase kinases (MAP3Ks), such as the Raf isoforms. Hormones, growth and differentiating factors, or tumor promoters induce Raf activation via activation of Ras proteins. MEK2 is seven amino acids larger and shares 81% identity with MEK1. In cultured cells, MEK2 is activated by serum. In vitro, v-Raf phosphorylates and activatesMEK2. It is thought that all of these activated protein kinases are downstream of the Ras signal transduction pathway and represent an integral part of the Ras mitogenic signal.
The 96/MEK2 monoclonal antibody recognizes MEK2, regardless of phosphorylation status.
Specifications
| MEK2 | |
| 250μg/mL | |
| Monoclonal | |
| Mouse | |
| Cell Biology | |
| Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide. | |
| IgG2a | |
| Affinity Purified | |
| MAP Kinase Kinase 2; ERK Kinase |
| 96/MEK2 | |
| Western Blot | |
| Unconjugated | |
| RUO | |
| Canine, Chicken, Frog, Human, Mouse, Rat | |
| Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide. | |
| Primary | |
| Store undiluted at -20°C. |
For Research Use Only.