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NF-κB p65 Mouse, Unlabeled, Clone: 20, BD

Mouse Monoclonal Antibody

Marque:  BD Biosciences 610869

Informations supplémentaires : Poids : 0.01000kg

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Code produit. 15875679

  • 450.84€ / 1 kit
Date d’expédition estimée: 20-12-2021

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Description

Description

NF-κB is a ubiquitously expressed transcription factor that regulates many cytokine and Ig genes. It is involved in immune, inflammatory, viral, and acute phase responses. The most studied NF-κB complex consists of the p50 and p65 subunits, both containing a 300 amino acid region with homology to the Rel proto-oncogene product. The p50 subunit binds DNA, whereas the p65 subunit is responsible for the interaction of NF-κB with its inhibitor, IκB. In most cell types, the p50/p65 heterodimer is located within the cytoplasm complexed to IκB. This complex prevents nuclear translocation and activity of NF-κB. In response to stimuli such as cytokines, LPS, and viral infections, IκB is phosphorylated at critical residues. This phosphorylation induces dissociation of the IκB/NF-κB complex, allowing the free heterodimeric
NF-κB to form a heterotetramer that translocates to the nucleus. In the nucleus, it binds to the κB site within promoters and enhancers and functions as a transcriptional activator.

Immunofluorescence, Western Blotting

Spécification

Spécification

NF-κB p65
20
Unconjugated
Affinity Purified
Human NF-κB aa. 136-224
150μg
Cell Biology
Primary
Canine, Frog, Human, Rabbit, Rat
Western Blot
250μg/mL
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Mouse
IgG1
RUO
Store undiluted at -20°C.
Monoclonal
Vidéos
FDS
Documents
Certificats
Promotions

Promotions

For Research Use Only.