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Occludin Mouse, Unlabeled, Clone: 19, BD

Mouse Monoclonal Antibody

330.00€ - 650.00€

Spécification

Antigène Occludin
Clone 19
Concentration 250μg/mL
Applications Western Blot
Classification Monoclonal
Consulter d'autres spécifications

Produits 2
Code produit Marque Quantité Prix Quantité et disponibilité  
Code produit Marque Quantité Prix Quantité et disponibilité  
15865789
Afficher les documents Détails de la promotion
BD Biosciences
611090
50 μg
330.00€
1 kit
Voir les produits de remplacement
Économisez jusqu'à 
»
Expédition estimée: 23-04-2024
pour voir le stock disponible 
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15875789
Afficher les documents Détails de la promotion
BD Biosciences
611091
150 μg
650.00€
1 kit
Voir les produits de remplacement
Économisez jusqu'à 
»
Expédition estimée: 23-04-2024
pour voir le stock disponible 
Veuillez vous pour pouvoir commander cet article. Besoin d'un compte web? Créer le vôtre dès maintenant!
Description

Description

Tight junctions (zonulae occludens) are critical to the maintenance of cell polarity and intercellular barriers between epithelial and endothelial cells. Among the barriers formed by the tight junctions is the critical blood-brain barrier. Protein components of the tight junctions include actin filaments, symplekin, occludin, Rab3B, AF-6, 7H6, ZO-1 and ZO-2. The human occludin protein is 522 amino acids with four transmembrane domains in the first half of the protein. Two glycine/tyrosine-rich extracellular loops are involved in cell-cell interactions. In the cytoplasm, occludin interacts with ZO-1 through its intracellular C-terminus. A possible function of ZO-1 may be to link the adherens components, like occludin, to the submembraneous actin cytoskeleton. Experimental breakdown of the tight junctions at the blood-brain barrier results in redistribution of vinculin and loss of ZO-1 and Occludin. Taken together, these data indicate that occludin and ZO-1 are critical elements in the formation of tight junctions and may also serve an important role in signaling and tumor suppression.
Spécification

Spécification

Occludin
250μg/mL
Monoclonal
Mouse
Cell Biology
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
IgG1
Affinity Purified
19
Western Blot
Unconjugated
RUO
Canine, Human, Mouse, Rat
Mouse Occludin aa. 396-507
Primary
Store undiluted at -20°C.
Vidéos
FDS
Documents

Documents

Product Certifications

For Research Use Only.