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Phospho-SRC (Tyr419) Rabbit anti-Chicken, Human, Mouse, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Marque:  Invitrogen 44660G

Code nomenclature Nacres: NA.41

Informations supplémentaires : Poids : 0.50000kg

Code produit. 10159302

  • 381.15€ / 1 pièce

Stock EU 3

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Description

Description

SRC is a non-receptor kinase involved in the regulation of growth and differentiation of eukaryotic cells. SRC associates with the cytoplasmic region of various cell surface receptors to facilitate signal transduction, and is also involved in cytoskeletal organization, cell cycle regulation, and apoptosis. In humans, the gene encoding SRC is present on chromosome 20. Activity of SRC is regulated by two tyrosine residues (Tyr419 and Tyr530), and phosphorylation of these two sites have opposing effects. Phosphorylation of Tyr419 in the activation loop of the kinase domain upregulates enzyme activity while the phosphorylation of Tyr530 decreases enzyme activity. Mutations in the SRC gene could be involved in the maligt progression of colon cancer. Two transcript variants encoding the same SRC protein have been found thus far.
Spécification

Spécification

Phospho-SRC (Tyr419)
Polyclonal
Dulbecco′s PBS with 1mg/mL BSA, 50% glycerol and 0.05% sodium azide; pH 7.3
P00523, P12931, P05480
EC 2.7.10.2, p60-Src, c-Src, pp60c-src
Rabbit
IgG
100 μL
-20°C
Primary
20779, 396442, 6714
Immunohistochemistry (Paraffin), Western Blot
Unconjugated
SRC
Liquid
SRC
The antiserum was produced against a chemically synthesized phosphopeptide derived from the region of human Src that contains tyrosine 419. The sequence is conserved in mouse, rat, chicken and frog.
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Chicken, Human, Mouse
Vidéos
Documents