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PKA [RI] Mouse, Unlabeled, Clone: 18, BD

Mouse Monoclonal Antibody

Marque:  BD Biosciences 610165

Informations supplémentaires : Poids : 0.01100kg

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Code produit. 15875299

  • 267.24€ / 1 kit
Date d’expédition estimée: 28-12-2021

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Description

Description

cAMP-dependent Protein Kinase (PKA) is composed of two distinct subunits: catalytic (C) and regulatory (R). Four regulatory subunits have been identified: RIα, RIβ, RIIα, and RIIβ. These subunits define type I and II cAMP-dependent protein kinases. Following binding of cAMP, the regulatory subunits dissociate from the catalytic subunits, rendering the enzyme active. Type I and type II holoenzymes have three potential C subunits (Cα, Cβ, or Cγ). Type II PKA can be distinguished by autophosphorylation of the R-subunits, while type I PKA binds Mg/ATP with high affinity. Most cells express both type I and type II PKAs. Although the Rα isoforms are ubiquitously expressed, the Rβ isoforms are predominant in nervous and adipose tissues. The levels of expression of the different subunits vary according to cell and tissue type.

Bioimaging, Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Western Blotting

Spécification

Spécification

PKA [RI]
18
Unconjugated
Affinity Purified
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
50μg
Cell Biology
Primary
Canine, Chicken, Frog, Human, Murine, Rat
Western Blot
250μg/mL
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Mouse
IgG2b
RUO
Store undiluted at -20°C.
Monoclonal
Vidéos
FDS
Documents
Certificats
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Promotions

For Research Use Only.