missing translation for 'onlineSavingsMsg'
Learn More

PKA RIIβ Mouse, Unlabeled, Clone: 45, BD

Mouse Monoclonal Antibody

Marque:  BD Biosciences 610625

Informations supplémentaires : Poids : 0.01000kg

 Afficher plus de versions de ce produit

Code produit. 15875549

  • 271.32€ / 1 kit
Date d’expédition estimée: 23-12-2021

Veuillez vous pour pouvoir commander cet article. Besoin d'un compte web? Créer le vôtre dès maintenant!


Description

Description

cAMP-dependent Protein Kinase (PKA) is composed of two distinct subunits: catalytic (C) and regulatory (R). Four regulatory subunits have been identified: RIα, RIβ, RIIα, and RIIβ.These subunits define type I and II cAMP-dependent protein kinases. Following binding of cAMP, the regulatory subunits dissociate from the catalytic subunits, rendering the enzyme active. Type I and type II holoenzymes have three potential C subunits (Cα, Cβ, or Cγ). Type II PKA can be distinguished by autophosphorylation of the R-subunits, while type I PKA binds Mg/ATP with high affinity. Most cells express both type I and type II PKAs. Although the Rα isoforms are ubiquitously expressed, the Rβ isoforms are predominant in nervous and adipose tissues. There are indications that the deletion of the gene for PKA RIIβ results in lack of long-term potentiation in a select group of hippocampal cells, suggesting an important role for this protein in the neurosciences.

Immunofluorescence, Immunoprecipitation, Western Blotting

Spécification

Spécification

PKA RIIβ
45
Unconjugated
Affinity Purified
Human PKA RIIβ, aa 1-418
50μg
Cell Biology
Primary
Canine, Chicken, Human, Murine, Rat
Western Blot
250μg/mL
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Mouse
IgG1
RUO
Store undiluted at -20°C.
Monoclonal
Vidéos
FDS
Documents
Certificats
Promotions

Promotions

For Research Use Only.