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Stat1 Mouse, Unlabeled, Clone: 1/STAT1, BD

Mouse Monoclonal Antibody

330.00€ - 545.00€

Spécification

Antigène Stat1
Clone 1/STAT1
Concentration 250μg/mL
Applications Western Blot
Classification Monoclonal
Consulter d'autres spécifications

Produits 2
Code produit Marque Quantité Prix Quantité et disponibilité  
Code produit Marque Quantité Prix Quantité et disponibilité  
15865269
Afficher les documents Détails de la promotion
BD Biosciences
610115
50 μg
330.00€
1 kit
Voir les produits de remplacement
Économisez jusqu'à 
»
Expédition estimée: 23-04-2024
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15875269
Afficher les documents Détails de la promotion
BD Biosciences
610116
150 μg
545.00€
1 kit
Voir les produits de remplacement
Économisez jusqu'à 
»
Expédition estimée: 23-04-2024
pour voir le stock disponible 
Veuillez vous pour pouvoir commander cet article. Besoin d'un compte web? Créer le vôtre dès maintenant!
Description

Description

Stat (Signal transducer and activators of transcription) proteins are critical mediators of the biologic activity of cytokines, including interleukins, interferons, erythropoietin, and growth factors. Ligand-receptor interaction leads to activation of constitutively associated JAK family kinases and subsequent recruitment/activation of Stat proteins by tyrosine phosphorylation. Active Stat proteins then move to the nucleus to promote transcription of cytokine-inducible genes. Seven Stat proteins have been cloned, each of which is differentially expressed and/or activated in a cytokine-specific and cell type-specific manner. Stat1 and Stat2 are components of the ISGF3 (Interferon-Stimulated Gene Factor 3) complex, which is the primary transcription activator induced by the binding of the interferon to a specific cell-surface receptor. Stat1 has two alternatively spliced isoforms, 91kDa Stat1α and 84kDa Stat1β; Stat1α has 38 additional C-terminal amino acids. In response to the binding of IFNα, IFNγ, EGF, PDGF, or CSF-1 to their respective receptors, the Stat1 subunits become tyrosine-phosphorylated at Y701, and the complex is translocated to the nucleus. This results in the formation of an active complex that includes the DNA-binding p48 subunit. This complex is responsible for modulating the transcription of the interferon-stimulated genes (ISGs). Thus, phosphorylation of Y701 in Stat1 occurs in response to growth factors and cytokines, and is essential for normal transcriptional activity of the ISGF3 complex.

Host Species: Mouse
Clone: 1
Isotype: IgG1
Species Reactivity: Human
Immunogen: Human Stat1 aa. 1-194
Formula Weight [Chemical]: 91/84kDa

Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Western Blotting

Spécification

Spécification

Stat1
250μg/mL
Monoclonal
Mouse
Cell Biology
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
IgG1
Affinity Purified
1/STAT1
Western Blot
Unconjugated
RUO
Canine, Chicken, Frog, Human, Mouse, Rat
Human Stat1 aa. 1-194
Primary
Store undiluted at -20°C.
Vidéos
FDS
Documents

Documents

Product Certifications

For Research Use Only.