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ARHGEF7 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Marque:  Proteintech 14092-1-AP-150UL

Informations supplémentaires : Poids : 0.00010kg

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Code produit. 16802584

  • 329.85€ / 150µL

Date d’expédition estimée: 22-06-2021

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Description

Description

The serine/threonine kinase, p21 activated kinase (PAK), is a downstream effector of the small GTPases Cdc42 and Rac. PAK associates with Nck, the p85 and p110 subunits of PI3-kinase and PIX (PAK-interacting exchange factor) in a focal complex. The binding of PIX is necessary for the localization and activation of PAK in the Cdc42 to Rac signaling pathway, and this binding occurs through the high affinity of the N-terminal SH3 domain of PIX for a conserved proline rich PAK sequence. PIX exists as two isoforms, alpha and beta, and both are highly expressed in heart, muscle and thymus tissues of human and rat. alphaPIX is phosphorylated via PDGF and EphB2 receptor signaling pathways or through association with PI3-kinase. The alphaPIX isoform predomitly acts as a guanine nucleotide exchange factor (GEF) on Rac, which may mediate lamellipodia formation.
Spécification

Spécification

ARHGEF7
0.27 mg/mL
PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
O55043, Q14155, Q9ES28
ARHGEF7, BETA PIX, COOL 1, COOL1, KIAA0142, KIAA0412, Nbla10314, P50, P50BP, P85, P85COOL1, P85SPR, PAK3, PAK3BP, PIXB
Rabbit
IgG
150 μL
-20°C
Primary
114559, 54126, 8874
Immunocytochemistry, Immunofluorescence, Immunoprecipitation, Western Blot
Unconjugated
ARHGEF7
Liquid
Arhgef7
ARHGEF7 Fusion Protein Ag5223
Antigen Affinity Chromatography
RUO
Antibody
Polyclonal
Human, Mouse, Rat
Vidéos
FDS
Documents
Certificats