AVPR1B Rabbit anti-Human, Polyclonal, Proteintech
Rabbit Polyclonal Antibody
Marque: Proteintech 55142-1-AP-150UL
Informations supplémentaires : Poids : 0.00010kg
DescriptionVasopressin V1B receptor expression has been documented in the pituitary, pituitary tumors, pheochromocytoma, breast cancer, and small-cell lung carcinomas. G-protein Coupled Receptors (GPCRs) comprise one of the largest families of signaling molecules with more than a thousand members currently predicted to exist. All GPCRs share a structural motif consisting of seven membrane-spanning helices, and exist in both active and inactive forms. An array of activating ligands participate in the conformation of GPCRs which leads to signaling via G-proteins and downstream effectors. Ongoing studies have also shown the vast series of reactions which participate in the negative regulation of GPCRs. This turn-off activity has tremendous implications for the physiological action of the cell, and continues to drive pharmacological research for new drug candidates. Two blockbuster drugs which have been developed as GPCR-targeted pharmaceuticals are Zyprexa (Eli Lilly) and Claritin (Schering-Plough) which have multi-billion dollar shares of the mental health and allergy markets, respectively.
|PBS with 50% glycerol and 0.1% sodium azide; pH 7.3|
|AVPR V1b, AVPR V3, AVPR1B, AVPR3, V1bR, Vasopressin V1b receptor, Vasopressin V3 receptor, VPR3|
|Antigen Affinity Chromatography|