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AVPR1B Rabbit anti-Human, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Marque:  Proteintech 55142-1-AP-150UL

Informations supplémentaires : Poids : 0.00010kg

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Code produit. 16806615

  • 329.85€ / 150µL

Expédition estimée
03-03-2021

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Description

Description

Vasopressin V1B receptor expression has been documented in the pituitary, pituitary tumors, pheochromocytoma, breast cancer, and small-cell lung carcinomas. G-protein Coupled Receptors (GPCRs) comprise one of the largest families of signaling molecules with more than a thousand members currently predicted to exist. All GPCRs share a structural motif consisting of seven membrane-spanning helices, and exist in both active and inactive forms. An array of activating ligands participate in the conformation of GPCRs which leads to signaling via G-proteins and downstream effectors. Ongoing studies have also shown the vast series of reactions which participate in the negative regulation of GPCRs. This turn-off activity has tremendous implications for the physiological action of the cell, and continues to drive pharmacological research for new drug candidates. Two blockbuster drugs which have been developed as GPCR-targeted pharmaceuticals are Zyprexa (Eli Lilly) and Claritin (Schering-Plough) which have multi-billion dollar shares of the mental health and allergy markets, respectively.
Spécification

Spécification

AVPR1B
0.2 mg/mL
PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
P47901
AVPR V1b, AVPR V3, AVPR1B, AVPR3, V1bR, Vasopressin V1b receptor, Vasopressin V3 receptor, VPR3
Rabbit
IgG
150 μL
-20°C
Primary
553
Immunohistochemistry (Paraffin)
Unconjugated
AVPR1B
Liquid
AVPR1B
Peptide
Antigen Affinity Chromatography
RUO
Antibody
Polyclonal
Human
Vidéos
FDS
Documents