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B23/NPM1 Rabbit anti-Human, Rat, Polyclonal, Proteintech
Rabbit Polyclonal Antibody
140.00€ - 399.00€
Spécification
Antigène | B23/NPM1 |
---|---|
Concentration | 0.2 mg/mL |
Applications | Immunocytochemistry, Immunoprecipitation, Western Blot, Immunohistochemistry (Paraffin), Immunofluorescence |
Classification | Polyclonal |
Conjugué | Unconjugated |
Code produit | Marque | Quantité | Prix | Quantité et disponibilité | |||||
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Code produit | Marque | Quantité | Prix | Quantité et disponibilité | |||||
16846603
|
Proteintech
10306-1-AP-20UL |
20 μL |
140.00€
20µL |
Expédition estimée: 13-05-2024 Connectez-vous pour voir le stock disponible |
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16836603
|
Proteintech
10306-1-AP-150UL |
150 μL |
399.00€
150µL |
Expédition estimée: 13-05-2024 Connectez-vous pour voir le stock disponible |
Veuillez vous connecter pour pouvoir commander cet article. Besoin d'un compte web? Créer le vôtre dès maintenant! | ||||
Description
NPM1 (Nucleophosmin 1, B23, nutramin, NO38) is a ubiquitously expressed phosphoprotein involved in ribosome assembly/transport, cytoplasmic/nuclear trafficking, regulation of DNA polymerase alpha activity, centrosome duplication, and regulation of p53. NPM1 continuously shuttles between the nucleus, cytoplasm, nucleolus and chaperoning core histones from the nucleus to the cytoplasm. NPM1 has been shown to bind nucleic acid, prevent protein aggregation via its chaperon activities, protect enzymes during thermal denaturation, and facilitate renaturation of chemically denatured proteins. In its cellular structure role, there is evidence suggesting NPM1 is associated with the centrosome, and is the substrate of CDK2/cyclin E during duplication of centrosomes (cellular division). Due to the NPM1 gene interaction with several tumor-associated chromosome translocations, NPM1 is thought to be a portion of several fusion proteins: NPM-ALK, NPM-RAR, and NPM-MLF1. While it is not thought to be part of the transforming potential of these fusion proteins, NPM1 is believed to act as the interface for oligomerization and oncogenic conversion of these tumor promoting fusion proteins. Further, NPM1 is also known to sequester the tumor suppressor RF in the nucleolus, protecting it from degradation until it is necessary. Dysfunction of the NPM1 protein is associated with diseases such as acute myeloid leukemia and lymphomatoid papulosis.Spécification
B23/NPM1 | |
Immunocytochemistry, Immunoprecipitation, Western Blot, Immunohistochemistry (Paraffin), Immunofluorescence | |
Unconjugated | |
Rabbit | |
Rat, Human | |
P06748, P13084 | |
25498, 4869 | |
B23/NPM1 Fusion Protein Ag0286 | |
Primary | |
-20°C | |
NPM1 |
0.2 mg/mL | |
Polyclonal | |
Liquid | |
RUO | |
PBS with 50% glycerol and 0.1% sodium azide; pH 7.3 | |
B23, NPM1, Nucleolar phosphoprotein B23, Nucleolar protein NO38, Nucleophosmin, Numatrin | |
NPM1 | |
IgG | |
Antigen Affinity Chromatography | |
Antibody |