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ACROBiosystems Biotinylated Human CD23 / Fc epsilon RII Protein, His, Avitag™
Biotinylated Protein
423.38€ - 1862.87€
Spécification
Numéro d’adhésion | AAH14108.1 |
---|---|
Poids moléculaire | 34.2 kDa |
Source | Biotinylated Human CD23, His,Avitag (CD3-H82Q5) is expressed from human 293 cells (HEK293). It contains AA Asp 48 - Ser 321 (Accession # P06734-1). |
Immunogène | Asp 48 - Ser 321 |
Conditions de stockage | -20°C |
Code produit | Marque | Quantité | Prix | Quantité et disponibilité | |||||
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Code produit | Marque | Quantité | Prix | Quantité et disponibilité | |||||
15866177
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ACROBiosystems
CD3-H82Q5-25UG |
25 μg |
423.38€
25µg |
Expédition estimée: 30-04-2024 Connectez-vous pour voir le stock disponible |
Veuillez vous connecter pour pouvoir commander cet article. Besoin d'un compte web? Créer le vôtre dès maintenant! | ||||
15856177
|
ACROBiosystems
CD3-H82Q5-200UG |
200 μg |
1862.87€
200µg |
Expédition estimée: 30-04-2024 Connectez-vous pour voir le stock disponible |
Veuillez vous connecter pour pouvoir commander cet article. Besoin d'un compte web? Créer le vôtre dès maintenant! | ||||
Description
Cluster of differentiation 23 (CD23) is also known as Low affinity immunoglobulin epsilon Fc receptor (FCER2), C-type lectin domain family 4 member J (CLEC4J), Fc-epsilon-RII (FcεRII), Immunoglobulin E-binding factor (IGEBF), is the low-affinity receptor for IgE, an antibody isotype involved in allergy and resistance to parasites, and is important in regulation of IgE levels. Unlike many of the antibody receptors, CD23 is a C-type lectin. It is found on mature B cells, activated macrophages, eosinophils, follicular dendritic cells, and platelets.There are two forms of CD23: CD23a and CD23b. CD23a is present on follicular B cells, whereas CD23b requires IL-4 to be expressed on T-cells, monocytes, Langerhans cells, eosinophils, and macrophages. CD23 is known to have role of transportation in antibody feedback regulation. Antigen that enters the blood stream is captured by antigen specific IgE antibodies. The IgE immune complexes that are formed bind to CD23 molecules on B cells, and are transported to the B cell follicles of the spleen. The antigen is then transferred from CD23+ B cells to CD11c+ antigen presenting cells. The CD11c+ cells in turn present the antigen to CD4+ T cells, which can lead to an enhanced antibody response. In flow cytometry, CD23 is helpful in the differentiation of chronic lymphocytic leukemia (CD23-positive) from mantle cell leukemia (CD23-negative).
This protein carries a polyhistidine tag at the N-terminus, followed by an Avi tag (Avitag™). The protein has a calculated MW of 34.2 kDa. The protein migrates as 40-46 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.Spécification
AAH14108.1 | |
Biotinylated Human CD23, His,Avitag (CD3-H82Q5) is expressed from human 293 cells (HEK293). It contains AA Asp 48 - Ser 321 (Accession # P06734-1). | |
-20°C | |
CD23 | |
Human | |
PBS, pH7.4 | |
HEK293 | |
MABSol™ Biotin Labeled Proteins |
34.2 kDa | |
Asp 48 - Ser 321 | |
FCER2,CD23,CD23A,CLEC4J,FCE2,IGEBF,FcεRII,FcεRII | |
Precision Avi | |
His Tag and Avi Tag | |
Less than 1.0 EU / μg by the LAL method. | |
Powder | |
>95% as determined by reduced SDS-PAGE |