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ACROBiosystems Biotinylated Human CD40 / TNFRSF5 Protein, Fc,Avitag™
MALS verified
Marque: ACROBiosystems TN5-H82F9-25UG
Informations supplémentaires : Poids : 0.00001kg
Description
CD40 is also known as TNFRSF5, Bp50, CDW40, MGC9013, TNFRSF5 and p50, is a member of the TNF receptor superfamily which are single transmembrane-spanning glycoproteins, and plays an essential role in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. CD40 is a costimulatory protein found on antigen presenting cells and is required for their activation. The binding of CD154 (CD40L) on TH cells to CD40 activates antigen presenting cells and induces a variety of downstream effects. CD40 contains 4 cysteine-rich repeats in the extracellular domain, and is expressed in B cells, dendritic cells, macrophages, endothelial cells, and several tumor cell lines.
This protein carries a human IgG1 Fc tag at the C-terminus, followed by a Avi tag (Avitag™). The protein has a calculated MW of 48.1 kDa. The protein migrates as 60-66 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.Spécification
| AAH12419.1 | |
| 25 μg | |
| Glu 21 - Arg 193 | |
| CD40,Bp50,CDW40,MGC9013,TNFRSF5,p50 | |
| Precision Avi | |
| Fc Tag and Avi Tag | |
| Less than 1.0 EU / μg by the LAL method. | |
| Powder | |
| >95% as determined by SDS-PAGE |
| 48.1 kDa | |
| Biotinylated Human CD40, Fc,Avitag™ (MALS verified) (TN5-H82F9) is expressed from human 293 cells (HEK293). It contains AA Glu 21 - Arg 193 (Accession # P25942-1). | |
| -20°C | |
| CD40 | |
| Human | |
| Tris with Glycine, Arginine and NaCl, pH7.5 | |
| HEK293 | |
| MABSol™ Biotin Labeled Proteins |