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ACROBiosystems Biotinylated Mouse PCSK9 Protein, Avitag™,His Tag

Biotinylated Protein

Marque:  ACROBiosystems PC9-M82E1-25UG

Informations supplémentaires : Poids : 0.00001kg

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Code produit. 15877437

  • 353.08€ / 25µg
Date d’expédition estimée: 07-01-2022

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Description

Description

Proprotein convertase subtilisin/kexin type 9 (PCSK9) is also known as NARC1 (neural apoptosis regulated convertase), is a newly identified subtilase belonging to the peptidase S8 subfamily. Mouse PCSK9 is synthesized as a soluble zymogen, and undergoes autocatalytic intramolecular processing in the endoplasmic reticulum, resulting in the cleavage of its propeptide that remains associated with the secreted active enzyme with a broad alkaline pH optimum. This protein plays a major regulatory role in cholesterol homeostasis. PCSK9 binds to the epidermal growth factor-like repeat A (EGF-A) domain of the low-density lipoprotein receptor (LDLR), inducing LDLR degradation. PCSK9 may also have a role in the differentiation of cortical neurons. Mutations in this gene have been associated with a rare form of autosomal dominant familial hypercholesterolemia (HCHOLA3).

This protein carries an Avi tag (Avitag™) at the C-terminus, followed by a polyhistidine tag. This protein undergoes autocatalytic cleavage to release the pro-peptide and mature chain. The pro-peptide and mature chain are associated through non‐covalent i
Spécification

Spécification

AAH38085.1
HEK293
Mouse
13.9 kDa and 61.0 kDa
25 µg
Gln 35 - Gln 694
PCSK9,FH3,HCHOLA3,LDLCQ1,NARC1,PC9
Precision Avi
PBS, pH7.4
Less than 1.0 EU / µg by the LAL method.
MABSol™ Biotin Labeled Proteins
Powder
>95% as determined by SDS-PAGE
MABSol™ Biotinylated Mouse PCSK9, Avitag,His Tag (PC9-M82E1) is expressed from human HEK293 cells. It contains AA Gln 35 - Gln 694 (Accession # AAH38085.1).
-20°C
PCSK9
His Tag and Avi Tag
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