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C4-B alpha chain/C4b-B/C4d-B Rabbit anti-Human, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Marque:  Proteintech 55228-1-AP-20UL

Informations supplémentaires : Poids : 0.00010kg

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Code produit. 16806725

  • 112.71€ / 20µL

Expédition estimée
26-02-2021

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Description

Description

This antibody raised against 1116-1128aa of human C4-B protein can recognize C4-B precursor, C4-B alpha chain, C4b-B, and C4d-B.

This gene encodes the basic form of complement factor 4, part of the classical activation pathway. The protein is expressed as a single chain precursor which is proteolytically cleaved into a trimer of alpha, beta, and gamma chains prior to secretion. The trimer provides a surface for interaction between the antigen-antibody complex and other complement components. The alpha chain may be cleaved to release C4 anaphylatoxin, a mediator of local inflammation. Deficiency of this protein is associated with systemic lupus erythematosus. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. Varying haplotypes of this gene cluster exist, such that individuals may have 1, 2, or 3 copies of this gene. In addition, this gene exists as a long form and a short form due to the presence or absence of a 6.4 kb endogenous HERV-K retrovirus in intron 9.
Spécification

Spécification

C4-B alpha chain/C4b-B/C4d-B
0.4 mg/mL
PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
P0C0L5
C4, C4B, C4B1, C4B12, C4B2, C4B3, C4B5, C4F, CH, CO4, Complement C4-B, CPAMD3
Rabbit
IgG
20 μL
-20°C
Primary
721
Western Blot
Unconjugated
C4B
Liquid
C4B
Peptide
Antigen Affinity Chromatography
RUO
Antibody
Polyclonal
Human
Vidéos
FDS
Documents