missing translation for 'onlineSavingsMsg'
Learn More
Learn More
CACNA1A Rabbit anti-Human, Polyclonal, Proteintech
Rabbit Polyclonal Antibody
Marque: Proteintech 27227-1-AP-20UL
Informations supplémentaires : Poids : 0.00010kg
Description
Voltage-dependent calcium channels mediate the entry of calcium ions into excitable cells, and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, and gene expression. Calcium channels are multisubunit complexes composed of alpha-1, beta, alpha-2/delta, and gamma subunits. The channel activity is directed by the pore-forming alpha-1 subunit, whereas, the others act as auxiliary subunits regulating this activity. The distinctive properties of the calcium channel types are related primarily to the expression of a variety of alpha-1 isoforms, alpha-1A, B, C, D, E, and S. This gene encodes the alpha-1A subunit, which is predomitly expressed in neuronal tissue. Mutations in this gene are associated with 2 neurologic disorders, familial hemiplegic migraine and episodic ataxia 2. This gene also exhibits polymorphic variation due to n-repeats. Multiple transcript variants encoding different isoforms have been found for this gene. In one set of transcript variants, the n-repeats occur in the 3 UTR, and are not associated with any disease. But in another set of variants, an insertion extends the coding region to include the n-repeats which encode a polyglutamine tract. Expansion of the n-repeats from the normal 4-16 to 21-28 in the coding region is associated with spinocerebellar ataxia 6.Spécification
CACNA1A | |
Polyclonal | |
Unconjugated | |
CACNA1A | |
APCA, BI, Brain calcium channel I, CACH4, CACN3, CACNA1A, CACNL1A4, CAV2.1, EA2, FHM, HPCA, MHP, MHP1, SCA6 | |
Rabbit | |
Antigen Affinity Chromatography | |
RUO | |
773 | |
-20°C | |
Liquid |
Immunohistochemistry (Paraffin) | |
0.5 mg/mL | |
PBS with 50% glycerol and 0.1% sodium azide; pH 7.3 | |
O00555 | |
CACNA1A | |
CACNA1A Fusion Protein Ag25943 | |
20 μL | |
Primary | |
Human | |
Antibody | |
IgG |