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CD11b Rat anti-Mouse, eFluor® 450, Clone: M1/70, eBioscience™

Rat Monoclonal Antibody

Marque:  Affymetrix eBioscience 48-0112-80

Code nomenclature Nacres: NA.41

Informations supplémentaires : Poids : 0.25000kg

 Afficher plus de versions de ce produit

Code produit. 15331690

  • 87.75€ / 25µg

En stock, prêt à être expédié : 3

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Description

Description

Excitation: 405 nm; Emission: 445 nm; Laser: Violet Laser. Filtration: 0.2 μm post-manufacturing filtered. CD11b (integrin alpha-M, ITGAM, integrin alpha-X, ITGAX) is a 165 kDa adhesion molecule that associates non-covalently with integrin beta-2 (CD18). The CD11b/CD18 heterodimeric complex is also known as integrin alpha-M beta-2, Mac-1, and CR3 (complement receptor 3). CD11b is expressed on the surface of monocytes/macrophages, granulocytes, activated lymphocytes, a subset of NK cells, a subset of dendritic cells, and microglia in the brain. CD11b/CD18 functions as the receptor for ICAM-1 (CD54), ICAM-2 (CD102), ICAM-4 (CD242), CD14, CD50, CD23, heparin, iC3b, fibrinogen, and Factor X -these adhesions are critical for cell-cell and cell-matrix interactions. CD11b is expressed on 8% of spleen cells, 44% of bone marrow cells, and less than 1% of thymocytes, and is commonly used as a microglial marker in nervous tissue. The expression of CD11b increases during monocyte maturation and expression levels vary on tissue macrophages. Further, peritoneal macrophages are reported to express higher levels of CD11b than splenic macrophages. Diseases associated with CD11b dysfunction include systemic lupus erythematosus 6 and ITGAM-related susceptibility to systemic lupus erythematosus.
Spécification

Spécification

CD11b
Monoclonal
0.2 mg/mL
PBS with 0.1% gelatin and 0.09% sodium azide; pH 7.2
P05555
CD11B; CR3A; MAC-1; MAC1A; MGC117044; MO1A; SLEB6; Integrin alpha M; HCD11B
Rat
Affinity chromatography
RUO
Antibody
Monoclonal
Mouse
Flow Cytometry
M1/70
eFluor™ 450
Itgam
Liquid
Itgam
IgG2b, kappa
25 μg
4° C, store in dark, DO NOT FREEZE!
Primary
16409
Vidéos
Documents

For Research Use Only.