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CD184 (CXCR4) Mouse, anti-Human, PE, Clone: 12G5, STEMCELL Technologies
Mouse Monoclonal Antibody
Marque: Stemcell Technologies 60089PE.1
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Description
- The 12G5 antibody reacts with CD184 (CXCR4 or fusin), an ∼45 kDa seven transmembrane G-protein-coupled receptor expressed on the surface of a broad range of cells, including T and B cells, dendritic cells, monocytes, macrophages, granulocytes, platelets, endothelial and epithelial cells, astrocytes and neurons
- At least two isoforms of CD184 are generated by alternate mRNA splicing
- Ligands for CD184 include the CXC chemokine SDF-1 and ubiquitin
- CD184 has functional roles in mediating chemotaxis, B cell lymphopoiesis and myelopoiesis, cardiogenesis, vascularization and neuronal guidance
- CD184 acts as a co-receptor for infection by some T cell-tropic isolates of HIV-1 and as an alternative receptor for CD4-independent infection by HIV-2; functions that are blocked by binding of the 12G5 antibody
- The antibody also partially inhibits SDF-1-induced chemotaxis and calcium influx
- CD184 is used along with other markers such as CD117 to monitor the emergence of definitive endoderm
Spécification
| CD184 (CXCR4) | |
| Monoclonal | |
| PE | |
| 25 Tests | |
| African Green Monkey, Baboon, Cynomolgus, Rhesus Monkey, Human | |
| Endoderm, PSC-Derived, Pluripotent Stem Cells |
| CyTOF, Flow Cytometry, Immunocytochemistry, Immunofluorescence, Functional Assay | |
| 12G5 | |
| Mouse | |
| Primary | |
| IgG2a κ |
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