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CD197 (CCR7) Monoclonal Antibody (3D12), PE-Cyanine5.5, eBioscience™, Invitrogen™
Rat Monoclonal Antibody
Marque: Affymetrix eBioscience 35-1979-42
Informations supplémentaires : Poids : 0.01000kg
Description
The 3D12 MAb reacts with human CCR7, also known as EBI-1 and CD197. CCR7 is a member of the G-protein-coupled chemokine receptor family with seven membrane-spanning domains and functions as a receptor for 6Ckine/SLC (secondary lymphoid-tissue chemokine), CCL19 and CCL21. CCR7 has been shown to be internalized via clathrin-coated pits and the majority recycled back to the plasma membrane. CCR7 is expressed on T cells and can be used to distinguish populations of naive from central and effector memory T cells. CCR7 has been shown to play a role in migration of memory T cells to inflamed tissue. Expression of CCR7 is also found on DC's. During DC maturation CCR7 expression increases and is thought to be involved in a variety of functions: chemotaxis to the lymph node, cellular architecture, rate of endocytosis, survival and maturation. Expression of CCR7 on the cell surface can be down regulated upon ligand binding.
CD197 (CCR7) Monoclonal antibody specifically detects CD197 (CCR7) in Human samples. It is validated for Flow Cytometry.Spécification
| CD197 (CCR7) | |
| Monoclonal | |
| 5 μL/Test | |
| PBS with 0.2% BSA and 0.09% sodium azide; pH 7.2 | |
| P32248 | |
| Ccr7 | |
| Affinity chromatography | |
| RUO | |
| 1236 | |
| 4° C, store in dark, DO NOT FREEZE! | |
| Liquid |
| Flow Cytometry | |
| 3D12 | |
| PE-Cyanine5.5 | |
| Ccr7 | |
| BLR2; Bukitt's lymphoma receptor 2; CC chemokine receptor 7; C-C chemokine receptor type 7; C-C CKR-7; C-C motif chemokine receptor 7; CC-CKR-7; CCR7; CCR-7; CD197; CDw197; chemokine (C-C motif) receptor 7; chemokine (C-C) receptor 7; Cmkbr7; EBI1; Ebi1h; EBV-induced G protein-coupled receptor 1; EBV-induced G-protein coupled receptor 1; Epstein-Barr virus induced gene 1; Epstein-Barr virus-induced G-protein coupled receptor 1; EVI1; lymphocyte-specific G protein-coupled peptide receptor; MIP-3 beta receptor | |
| Rat | |
| 100 Tests | |
| Primary | |
| Human | |
| Antibody | |
| IgG2a κ |