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CD204 Monoclonal Antibody (PSL204), APC, eBioscience™, Invitrogen™
Mouse Monoclonal Antibody
420.00€
Spécification
Antigène | CD204 |
---|---|
Clone | PSL204 |
Concentration | 5 μL/Test |
Applications | Flow Cytometry |
Classification | Monoclonal |
Code produit | Marque | Quantité | Prix | Quantité et disponibilité | |||||
---|---|---|---|---|---|---|---|---|---|
Code produit | Marque | Quantité | Prix | Quantité et disponibilité | |||||
15762466
|
Affymetrix eBioscience
17-2045-42 |
100 Tests |
420.00€
100 pièces |
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Description
This monoclonal antibody PSL204 reacts with human CD204, also known as Macrophage Scavenger Receptor 1 (MSR1), Scavenger Receptor Type A (SR-A), or SCARA1. It is expressed by multiple populations of macrophages and dendritic cells. CD204 belongs to the class A family of scavenger receptors, a group of five homotrimetric transmembrane proteins that contain a short cytoplasmic tail and extracellular C -terminus. Other members of this family include: MARCO (SCARA2), CSR (SCARA3), SRCL (SCARA4) and SCARA5. CD204 binds and internalizes oxidized low density lipoproteins (LDL), which drives macrophage differentiation into foam cells, secretion of inflammatory cytokines, and development of atherosclerotic lesions. In addition to oxidized LDL, CD204 binds and uptakes a wide variety of macromolecules, including bacterial cell wall components, viral DNA, calciprotein complexes, apoptotic cells, and beta-amyloid fibrils. This broad binding specificity implicates CD204-expressing macrophages in a number of physiological processes and pathologies, such as host defense, inflammation, bone remodeling, atherosclerosis, sepsis, and Alzheimer's disease. In humans, CD204 exists as 3 splice variants. The more ubiquitous full length isoform (type I, SR-AI), a shorter isoform (type II, SR-AII) that lacks the C-terminal cysteine-rich domain, and the shortest isoform (type III, SR-AIII).
CD204 Monoclonal antibody specifically detects CD204 in Human samples. It is validated for Flow Cytometry.Spécification
CD204 | |
5 μL/Test | |
Monoclonal | |
Liquid | |
RUO | |
P21757 | |
MSR1 | |
Primary | |
4° C, store in dark, DO NOT FREEZE! | |
MSR1 |
PSL204 | |
Flow Cytometry | |
APC | |
Mouse | |
Human | |
4481 | |
IgG1 κ | |
Affinity chromatography | |
Antibody |
For Research Use Only