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CD204 Monoclonal Antibody (M204PA), PE, eBioscience™, Invitrogen™

Rat Monoclonal Antibody

174.00€ - 417.00€

Spécification

Antigène CD204
Clone M204PA
Concentration 0.2 mg/mL
Applications Flow Cytometry
Classification Monoclonal
Consulter d'autres spécifications

Produits 2
Code produit Marque Quantité Prix Quantité et disponibilité  
Code produit Marque Quantité Prix Quantité et disponibilité  
16330604
Afficher les documents Détails de la promotion
Affymetrix eBioscience
12-2046-80
25 μg
174.00€
25µg
Voir les produits de remplacement
Économisez jusqu'à 
»
Expédition estimée: 16-04-2024
pour voir le stock disponible 
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16340604
Afficher les documents Détails de la promotion
Affymetrix eBioscience
12-2046-82
100 μg
417.00€
100µg
Voir les produits de remplacement
Économisez jusqu'à 
»
En stock
pour voir le stock disponible 
Veuillez vous pour pouvoir commander cet article. Besoin d'un compte web? Créer le vôtre dès maintenant!
Description

Description

This M204PA antibody recognizes mouse CD204 also known as Macrophage Scavenger Receptor 1 (MSR 1), Scavenger Receptor A (SR-A) or SCARA1. CD204 belongs to the class A family of scavenger receptors that are primarily responsible for binding a wide variety of macromolecules and are involved in many aspects of macrophage activity. Other members of this family include: MARCO (SCARA2), CSR (SCARA3), SRCL (SCARA4) and SCARA5. All class A scavenger receptors are trans-membrane proteins with extracellular C-termini and homotrimeric structures. CD204 exists as 2 splice variants: the more ubiquitous full length isoform (type I) and a shorter isoform (type II) that lacks the C-terminal cysteine-rich domain. Both types are functional and bind modified LDL with similar affinity. In addition to lipid metabolism, CD204 plays an important role suppressing inflammation and macrophage activation. CD204 is considered one of the markers of M2 and Tumor-Associated Macrophages. Interestingly, this molecule is responsible for adherence of RAW264.7 cells to tissue culture-treated plastic in the absence of Ca and Mg cations. This M204PA antibody binds to CD204 of multiple mouse strains, including C57Bl/6, Balb/c and Swiss-Webster (outbred). This antibody works on fixed cells and can be used to stain CD204 intracellularly. The M204PA antibody does not cross-react with human or rat. This antibody is not suitable for IHC staining.

CD204 gene encodes the class A macrophage scavenger receptors, which include three different types (1, 2, 3) generated by alternative splicing of this gene. These receptors or isoforms are macrophage-specific trimeric integral membrane glycoproteins and have been implicated in many macrophage-associated physiological and pathological processes including atherosclerosis, Alzheimer's disease, and host defense. The isoforms type 1 and type 2 are functional receptors and are able to mediate the endocytosis of modified low density lipoproteins (LDLs). The isoform type 3 does not internalize modified LDL (acetyl-LDL) despite having the domain shown to mediate this function in the types 1 and 2 isoforms. It has an altered intracellular processing and is trapped within the endoplasmic reticulum, making it unable to perform endocytosis. The isoform type 3 can inhibit the function of isoforms type 1 and type 2 when co-expressed, indicating a dominant negative effect and suggesting a mechanism for regulation of scavenger receptor activity in macrophages. Diseases associated with MSR1 include Barrett Esophagus and Prostate Cancer.
Spécification

Spécification

CD204
0.2 mg/mL
Monoclonal
Liquid
RUO
PBS with 0.09% sodium azide
bovine scavenger receptor type II; CD204; Macrophage acetylated LDL receptor I and II; macrophage scavenger receptor 1; macrophage scavenger receptor type III; macrophage scavenger receptor types I and II; MRS-A; MSR; Msr1; MSR-A; phSR1; phSR2; RGD1564316; SCARA1; Scavenger receptor class A member 1; scavenger receptor class A, member 1; scavenger receptor type A; scavenger receptor type I; Scvr; SRA; SR-A; SR-AI; SR-AI/II; SR-AII
MSR1
Primary
4° C, store in dark, DO NOT FREEZE!
MSR1
M204PA
Flow Cytometry
PE
Rat
Mouse
P30204
20288
IgG2a κ
Affinity chromatography
Antibody
Vidéos
FDS
Documents

Documents

Product Certifications

For Research Use Only.