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CD21/CD35 Rat anti-Mouse, APC, Clone: eBio4E3 (4E3), eBioscience

Rat Monoclonal Antibody

Marque:  Affymetrix eBioscience 17-0212-80

Informations supplémentaires : Poids : 0.01000kg

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Code produit. 16370664

  • 105.00€ / 2 pièces

Expédition estimée
17-11-2020

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Description

Description

Excitation: 633-647 nm; Emission: 660 nm; Laser: Red Laser CD21 (complement receptor 2, CR2) binds C3 complement fragments, especially its breakdown fragments, which remain covalently attached to complement activating surfaces or antigen. CD21 has important roles in uptake and retention of immunocomplexes, survival of memory B cells and in development and maintece of the humoral response to T-dependent antigens. CD21 also serves as a key receptor for Epstein-Barr virus binding and is involved in targeting prions to folicular dendritic cells and expediting neuroinvasion following peripheral exposure to prions. A soluble form of the CD21 (sCD21) is shed from the lymphocyte surface and retains its ability to bind respective ligands. CD35 encodes a membrane glycoprotein found on peripheral blood cells, glomerular podocytes, and follicular dendritic cells. The protein is a receptor for complement components C3b and C4b and regulates the activity of the complement cascade. Variation in this protein is the basis of the Knops blood group system. The two most common alleles, F and S, differ by 8 exons and are thought to be the result of an unequal crossover event. A secreted form of the protein present in plasma has been described, but its full length nature has not been determined.
Spécification

Spécification

CD21/CD35
Monoclonal
0.2 mg/mL
PBS with 0.09% sodium azide; pH 7.2
P19070
Cr2
IgG2a, lambda
25 μg
4° C, store in dark, DO NOT FREEZE!
Primary
12902
Flow Cytometry
eBio4E3 (4E3)
APC
Cr2
Liquid
Rat
Affinity Chromatography
RUO
Antibody
Monoclonal
Mouse
Vidéos
Documents