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CD223 (LAG-3) Monoclonal Antibody (eBioC9B7W (C9B7W)), FITC, eBioscience™, Invitrogen™

Rat Monoclonal Antibody

80.00€ - 190.00€

Spécification

Antigène CD223 (LAG-3)
Clone eBioC9B7W (C9B7W)
Concentration 0.5 mg/mL
Applications Flow Cytometry
Classification Monoclonal
Consulter d'autres spécifications

Produits 2
Code produit Marque Quantité Prix Quantité et disponibilité  
Code produit Marque Quantité Prix Quantité et disponibilité  
15546516
Afficher les documents Détails de la promotion
Affymetrix eBioscience
11-2231-80
25 μg
80.00€
25µg
Voir les produits de remplacement
Économisez jusqu'à 
»
Expédition estimée: 16-04-2024
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15556516
Afficher les documents Détails de la promotion
Affymetrix eBioscience
11-2231-82
100 μg
190.00€
100µg
Voir les produits de remplacement
Économisez jusqu'à 
»
Expédition estimée: 10-04-2024
pour voir le stock disponible 
Veuillez vous pour pouvoir commander cet article. Besoin d'un compte web? Créer le vôtre dès maintenant!
Description

Description

Description: The eBioC9B7W monoclonal antibody recognizes mouse CD223 (LAG-3, LAG3) protein expressed by activated alpha/beta-TCR bearing T cells, a subset of gamma/delta-TCR bearing T cells and a subset of NK cells. CD223 is a 70 kDa type I transmembrane protein with a structure that is similar to CD4. However, a soluble form of human CD223 has been detected by ELISA in human serum, and data suggest that mouse CD223 is proteolytically cleaved in the D4 domain. This results in a 54 kDa fragment containing all the extracellular domains, and a 16 kDa fragment containing the intracellular and transmembrane domains. The 54 kDa can remain membrane-associated or be released as soluble CD223. CD223 binds to MHC class II with higher affinity than CD4, and it is thought that this interaction is involved in the negative regulation of T-cell activation and homeostatic proliferation. Furthermore, CD223 is expressed by CD4+CD25+ regulatory T cells, and it has been suggested that CD223 may be involved in their regulatory function. Applications Reported: This eBioC9B7W (C9B7W) antibody has been reported for use in flow cytometric analysis. Applications Tested: This eBioC9B7W (C9B7W) antibody has been tested by flow cytometric analysis of stimulated mouse splenocytes. This can be used at less than or equal to 1 μg per test. A test is defined as the amount (μg) of antibody that will stain a cell sample in a final volume of 100 μL.

LAG-3 is a 70-kDa surface glycoprotein belonging to the Ig superfamily with homology to CD4. LAG-3 binds to MHC class II with higher affinity than CD4 and is thought to be involved in the negative regulation of T cell activation and homeostatic proliferation. Surface expression of LAG-3 has been reported on activated T cells (including regulatory T cells) and NK cells. CD8+ T cells usually express LAG-3 at significantly higher levels than CD4+ T cells. Coexpression of LAG-3 and CD49b has been proposed to identify human and mouse Type 1 regulatory T cells (Tr1 cells).
Spécification

Spécification

CD223 (LAG-3)
0.5 mg/mL
Monoclonal
Liquid
RUO
PBS with 0.09% sodium azide; pH 7.2
Activation-induced cytidine deaminase-linked autoimmunity protein; Aida; CD223; FDC; LAG3; LAG-3; Ly66; lymphocyte activating 3; lymphocyte activation gene 3 protein; lymphocyte-activation gene 3; Secreted lymphocyte activation gene 3 protein; sLAG 3; sLAG3; sLAG-3; soluble LAG 3lymphocyte activating 3; soluble LAG3
LAG3
Primary
4° C, store in dark, DO NOT FREEZE!
LAG3
eBioC9B7W (C9B7W)
Flow Cytometry
FITC
Rat
Mouse
Q61790
16768
IgG1 κ
Affinity chromatography
Antibody
Vidéos
FDS
Documents

Documents

Product Certifications

For Research Use Only.