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CD227 (Mucin 1) Monoclonal Antibody (SM3), eFluor™ 615, eBioscience™, Invitrogen™
Mouse Monoclonal Antibody
Marque: Affymetrix eBioscience 42-9893-82
Code nomenclature Nacres: NA.41
Informations supplémentaires : Poids : 0.25000kg
Description
Description: This SM3 monoclonal antibody reacts with the under-glycosylated form of human Mucin 1 (MUC1, CD227), a large glycoprotein belonging to the mucin protein family. Mucin 1 contains a polypeptide core consisting of multiple tandem repeats that become highly glycosylated. Mucin 1 is typically expressed in ductal or glandular epithelial cells and is localized to the apical membrane. In cancerous cells, Mucin 1 expression is increased and membrane-specific localization is lost resulting in expression throughout the membrane and cytoplasm. High levels of under-glycosylated Mucin 1 are thought to affect cell behavior during both invasion and metastasis as well as in immune recognition. In addition, under-glycosylated Mucin 1 is shed from the epithelial cell surface and can be detected in circulation. Alterations in Mucin 1 glycosylation are found in most adenocarcinomas of the breast, lung, pancreas, prostate, and ovary. Mucin 1 has recently been shown to co-localize and interact with members of the erbB receptor kinase family, proteins that are upregulated in more aggressive forms of breast cancer. Please note this antibody sees a distinct epitope from other Mucin 1 antibodies. Applications Reported: This SM3 antibody has been reported for use in immunohistochemical staining of formalin-fixed paraffin embedded tissue sections (IHC-P) and immunocytochemistry (ICC).
CD227 (Mucin 1) Monoclonal antibody specifically detects CD227 (Mucin 1) in Human samples. It is validated for Immunocytochemistry, Immunohistochemistry (Paraffin).Spécification
| CD227 (Mucin 1) | |
| Monoclonal | |
| 0.2 mg/mL | |
| PBS with 0.09% sodium azide; pH 7.2 | |
| P15941 | |
| MUC1 | |
| Affinity chromatography | |
| RUO | |
| 4582 | |
| 4° C, store in dark, DO NOT FREEZE! | |
| Liquid |
| Immunocytochemistry, Immunohistochemistry (Paraffin) | |
| SM3 | |
| eFluor 615 | |
| MUC1 | |
| ADMCKD; ADMCKD1; Breast carcinoma-associated antigen DF3; CA 15-3; Cancer antigen 15-3; carcinoma-associated mucin; CD227; DF3 antigen; EMA; Episialin; H23 antigen; H23AG; J19; KL-6; Krebs von den Lungen-6; MAM6; MCD; MCKD; MCKD1; Medullary cystic kidney disease, autosomal dominant; Muc1; MUC-1; MUC-1/SEC; MUC-1/X; MUC1/ZD; MUC1-alpha; MUC1-beta; MUC1-CT; MUC1-NT; mucin 1, cell surface associated; mucin 1, transmembrane; Mucin1; mucin-1; Mucin-1 subunit alpha; Mucin-1 subunit beta; peanut-reactive urinary mucin; PEM; PEMT; Polymorphic epithelial mucin; PUM; tumor associated epithelial mucin; tumor-associated epithelial membrane antigen; Tumor-associated mucin | |
| Mouse | |
| 100 μg | |
| Primary | |
| Human | |
| Antibody | |
| IgG1 |
For Research Use Only.