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CD244 Monoclonal Antibody (eBioC1.7 (C1.7)), Super Bright™ 600, eBioscience™, Invitrogen™

Mouse Monoclonal Antibody

367.00€

Spécification

Antigène CD244
Clone eBioC1.7 (C1.7)
Concentration 5 μL/Test
Applications Flow Cytometry
Classification Monoclonal
Consulter d'autres spécifications

Produits 1
Code produit Marque Quantité Prix Quantité et disponibilité  
Code produit Marque Quantité Prix Quantité et disponibilité  
15973554
Afficher les documents Détails de la promotion
Affymetrix eBioscience
63-5838-42
100 Tests
367.00€
100 pièces
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Expédition estimée: 23-04-2024
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Description

Description

Description: The eBioC1.7 monoclonal antibody reacts with human CD244 (2B4, p38). In human, CD244 is a 38 kDa protein expressed on NK cells, a subset of CD8+ T cells, gammadelta T cells, monocytes, basophils and eosinophils. Binding of the CD244 ligand, CD48, results in NK cell activation, unlike mouse CD244, which is an inhibitory receptor. For CD244 expressed on NK cells, binding of CD48 results in enhanced NK cell cytotoxicity and secretion of IFN-gamma. Recently, it was demonstrated that binding of the C1.7 monoclonal antibody and CD48 involve the same residue in the V domain of human CD244, which explains the ability of C1.7 binding to induce activation of NK cells. Binding of C1.7 to CD244 leads to tyrosine phosphorylation and recruitment of the adaptor molecule SAP (SLAM-associated protein). Patients with X-linked lymphoproliferative disorder (XLPD) have a mutation in SAP which renders it unable to bind to phosphorylated CD244. Applications Reported: This eBioC1.7 antibody has been reported for use in flow cytometric analysis. Applications Tested: This eBioC1.7 antibody has been pre-diluted and tested by flow cytometric analysis of normal human peripheral blood cells. This may be used at 5 μL (0.5 μg) per test. A test is defined as the amount (μg) of antibody that will stain a cell sample in a final volume of 100 μL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test.

CD244 Monoclonal antibody specifically detects CD244 in Human samples. It is validated for Flow Cytometry.
Spécification

Spécification

CD244
5 μL/Test
Monoclonal
Liquid
RUO
Q9BZW8
CD244
Primary
4° C, store in dark, DO NOT FREEZE!
CD244
eBioC1.7 (C1.7)
Flow Cytometry
Super Bright 600
Mouse
Human
51744
IgG1 κ
Affinity chromatography
Antibody
Vidéos
FDS
Documents

Documents

Product Certifications