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CD25 Rat anti-Mouse, FITC, Clone: PC61.5, eBioscience

Rat Monoclonal Antibody

Marque:  Affymetrix eBioscience 11-0251-82

Informations supplémentaires : Poids : 0.01000kg

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Code produit. 16370574

  • 155.00€ / 1 pièce

Expédition estimée
09-11-2020

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Description

Description

CD25 (IL2 receptor alpha chain/IL2RA) is a cytokine that plays a role in the proliferation of T and B lymphocytes. The receptor of this cytokine (IL2RA) is a heterotrimeric protein complex with a gamma chain also shared by interleukin 4 (IL4) and interleukin 7 (IL7). IL2RA, IL2R beta chain (IL2RB), and the IL2R gamma chain (IL2RG), constitute the high-affinity IL2 receptor. Homodimeric IL2RA chains result in low-affinity receptor, while homodimeric IL2RB chains produce a medium-affinity receptor. The expression of IL2 in mature thymocytes is monoallelic, which represents an unusual regulatory mode for controlling the precise expression of a single gene. IL2 is primarily produced by mature T cells. IL2 plays an important role as a growth factor, differentiation factor, and regulator of cell death. IL-2 stimulates the proliferation of B cells, augments natural killer cell activity, and inhibits granulocyte macrophage colony formation. The targeted disruption of a similar gene in mice leads to ulcerative colitis-like disease, which suggests a role in the immune response to antigenic stimuli. Mutations in this gene are associated with interleukin 2 receptor alpha deficiency.
Spécification

Spécification

CD25
Monoclonal
0.2 mg/mL
PBS with 0.09% sodium azide; pH 7.2
P01590
Il2ra
IgG1, lambda
100 μg
4° C, store in dark, DO NOT FREEZE!
Primary
16184
Flow Cytometry
PC61.5
FITC
Il2ra
Liquid
Rat
Affinity Chromatography
RUO
Antibody
Monoclonal
Mouse
Vidéos
Documents