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CD43 Mouse anti-Human, Clone: 2A11D6, Proteintech

Mouse Monoclonal Antibody

Marque:  Proteintech 66224-1-IG-150UL

Informations supplémentaires : Poids : 0.00010kg

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Code produit. 16837905

  • 325.38€ / 150µL
Expédition estimée: 30-09-2022
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Description

Description

CD43 (leukosialin, sialophorin) is a transmembrane mucin-like protein with high negative charge, expressed on the surface of most hematopoietic cells. CD43 contributes to a repulsive barrier that interferes with cellular adhesion, however, in certain cases also promotes leukocyte aggregation. By interaction with actin-binding proteins ezrin and moesin CD43 plays a regulatory role in remodeling T-cell morphology and regulates cell-cell interactions during lymphocyte traffic. CD43 signaling both enhances LFA-1 adhesiveness and counteracts LFA-1 induction via other receptors. Expression of CD43 causes induction of functionally active tumor suppressor p53 protein, but in case of p53 and ARF deficiency CD43 promotes tumor proliferation and viability. CD43 appears to be an important modulator of leukocyte functions. Diseases associated with CD43 dysfunction include Wiscott-Aldrich Syndrome and Adenoid Basal Cell Carcinoma.
Spécification

Spécification

CD43
Monoclonal
2 mg/mL
PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
P16150
SPN
CD43 Fusion Protein Ag23595
150 μL
Primary
Human
Antibody
IgG2b
Western Blot, Immunohistochemistry (Paraffin), Immunofluorescence, Immunocytochemistry
2A11D6
Unconjugated
SPN
CD43, Galactoglycoprotein, GALGP, GPL115, Leukocyte sialoglycoprotein, Leukosialin, LSN, sialophorin, SPN
Mouse
Protein A
RUO
6693
-20°C
Liquid
Vidéos
FDS
Documents
Certificats
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