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CD61 (Integrin beta 3) Armenian Hamster anti-Mouse, Rat, APC, Clone: 2C9.G3, Invitrogen™

Armenian Hamster Monoclonal Antibody

Marque:  Affymetrix eBioscience 17-0611-80

Informations supplémentaires : Poids : 0.01000kg

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Code produit. 16646304

  • 87.50€ / 2 pièces

Date d’expédition estimée: 29-10-2021

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Description

Description

Description: The 2C9.G3 (HMb3-1) monoclonal antibody reacts with mouse and rat CD61, also known as the integrin beta3. CD61 is expressed by activated T cells, granulocytes, and platelet. CD61 associates non-covalently with two integrin alpha subunits; alphaV (CD51) to form Vitronectin Receptor and alphaIib (CD41) to form gpIIb/IIIa. These heterodimeric complexes are responsible for adhesion to extracellular matrix components including fibrinogen, fibronectin, fibronectin, vitronectin, thrombospondin and von Willebrand factor. Applications Reported: This 2C9.G3 antibody has been reported for use in flow cytometric analysis. Applications Tested: This 2C9.G3 antibody has been tested by flow cytometric analysis of mouse bone marrow cells. This may be used at less than or equal to 0.125 μg per test. A test is defined as the amount (μg) of antibody that will stain a cell sample in a final volume of 100 μL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest. Excitation: 633-647 nm; Emission: 660 nm; Laser: Red Laser

CD61 (GPIIIa, ITGB3) is a glycoprotein found on megakaryocytes, platelets and their precursors. CD61 antigen plays a role in platelet aggregation and also as a receptor for fibrinogen, fibronectin, von Willebrand factor and vitronectrin. CD61 is a 105 kDa glycoprotein that associates with either the alpha 11b integrin (CD41) or the alpha V integrin (CD51) at the cell surface. CD61 is expressed on platelets and megakaryocytes in association with CD41, and on endothelial cells, monocytes, platelets and osteoclasts in association with CD51. CD61 is a receptor for fibrinogen, fibronectin, Von Willebrand Factor, vitronectin and thrombospondin. The CD61 protein product is composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. CD61 is found along with the alpha IIb chain in platelets. Like other integrins, CD61 is known to participate in cell adhesion as well as cell-surface mediated signaling. Diseases associated with CD61 dysfunction include Glanzmann Thrombasthenia and Platelet type-16 Bleeding Disorder.
Spécification

Spécification

CD61 (Integrin beta 3)
2C9.G3
APC
ITGB3
Liquid
ITGB3
IgG
25 μg
4°C, store in dark, DO NOT FREEZE!
Primary
16416, 29302
Flow Cytometry
0.2 mg/mL
PBS with 0.09% sodium azide; pH 7.2
O54890
antigen CD61; BDPLT16; BDPLT2; beta3 integrin; CD61; EGM_08034; glycoprotein GPIIIa; GP3A; GPIIIa; GT; hypothetical protein; INGRB3; integrin beta 3; integrin beta 3 (Cd61); Integrin beta-3; integrin subunit beta 3; integrin, beta 3; integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61); Itgb3; platelet glycoprotein IIIa integrin subunit beta 3; platelet gpIIIa; Platelet membrane glycoprotein IIIa
Armenian Hamster
Affinity chromatography
RUO
Antibody
Monoclonal
Mouse, Rat
Vidéos
FDS
Documents
Certificats