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Chk2 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

140.00€ - 399.00€

Spécification

Antigène Chk2
Concentration 0.23 mg/mL
Applications Immunoprecipitation, Immunocytochemistry, Immunofluorescence, Western Blot
Classification Polyclonal
Conjugué Unconjugated
Consulter d'autres spécifications

Produits 2
Code produit Marque Quantité Prix Quantité et disponibilité  
Code produit Marque Quantité Prix Quantité et disponibilité  
16812404
Afficher les documents Détails de la promotion
Proteintech
13954-1-AP-20UL
20 μL
140.00€
20µL
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»
Expédition estimée: 12-04-2024
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16802404
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Proteintech
13954-1-AP-150UL
150 μL
399.00€
150µL
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Économisez jusqu'à 
»
Expédition estimée: 12-04-2024
pour voir le stock disponible 
Veuillez vous pour pouvoir commander cet article. Besoin d'un compte web? Créer le vôtre dès maintenant!
Description

Description

Chk2 (checkpoint kinase 2) is the mammalian homolog of the Saccharomyces cerevisiae Rad53 and is required for the DNA damage and replication checkpoints. In response to low-dose ionizing radiation (IR), which occurs in an ataxia telangiectasia mutated (ATM)-dependent manner, Chk2 can phosphorylate the mitosis-inducing phosphatase Cdc25C on an inhibitory site, blocking entry into mitosis, and p53 on a regulatory site, causing G1 arrest. In human tissues, Chk2 is homogeneously expressed in renewing cell populations such as epidermis or intestine, heterogeneous in conditionally renewing tissues, and absent or at low level in static tissues such as muscle or brain. Mutations in Chk2 inactivates DNA damage checkpoint pathway involving Chk2 in lung cancer suggesting that reduced expression of Chk2 may be responsible for the development of lung cancer. The Chk2-/- knockout cells are resistant to DNA damage-induced apoptosis, defective for p53 stabilization and for induction of p53-dependent transcripts such as p21 in response to gamma irradiation.
Spécification

Spécification

Chk2
Immunoprecipitation, Immunocytochemistry, Immunofluorescence, Western Blot
Unconjugated
Rabbit
Rat, Human, Mouse
O96017, Q9Z265
11200, 114212, 50883
Chk2 Fusion Protein Ag5065
Primary
-20°C
CHEK2
0.23 mg/mL
Polyclonal
Liquid
RUO
PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
CDS1, CHEK2, Chk2, HuCds1, LFS2, PP1425, RAD53
Chek2
IgG
Antigen Affinity Chromatography
Antibody
Vidéos
FDS
Documents

Documents

Product Certifications