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Cryptochrome 1 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Marque:  Proteintech 13474-1-AP-20UL

Informations supplémentaires : Poids : 0.00010kg

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Code produit. 16801714

  • 112.71€ / 20µL

Expédition estimée
09-03-2021

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Description

Description

Various biochemical, physiological and behavioural processes display circadian rhythms controlled by an internal biological clock. The central "gears" driving this clock appear to be composed of an autoregulatory transcription/posttranslation-based feedback loop. Cryptochrome 1 (CRY1) and 2 (CRY2) are DNA-binding flavoproteins that bear some homology to blue-light receptors and photolyases. In Drosophila, CRY is a photoreceptor for the circadian clock where it binds to the clock component TIM in a light-dependent fashion and blocks its function. Mammalian CRY1 and CRY2 function via light-independent interactions with circadian genes CLOCK and BMAL1, as well as with PER1, PER2, and TIM. They seem to act as light-independent components of the circadian clock and likely regulate Per1 transcriptional cycling via interactions with both the activator and its feedback inhibitors. Mutant mice not expressing the Cry1 or Cry2 protein display accelerated and delayed periodicity of locomotor activity, respectively. It appears that the combination of both proteins working together is essential to synchronize the organism to circadian phases. A critical balance between Cry1 and Cry2 is required for proper clock function; in complete darkness, double-mutant mice present with instantaneous arrhythmicity, indicating the absence of an internal circadian clock.
Spécification

Spécification

Cryptochrome 1
0.19 mg/mL
PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
P97784, Q16526, Q32Q86
CRY1, Cryptochrome 1, PHLL1
Rabbit
IgG
20 μL
-20°C
Primary
12952, 1407, 299691
Western Blot, Immunohistochemistry (Paraffin), Immunocytochemistry, Immunofluorescence
Unconjugated
CRY1
Liquid
Cry1
Cryptochrome 1 Fusion Protein Ag4270
Antigen Affinity Chromatography
RUO
Antibody
Polyclonal
Mouse, Rat, Human
Vidéos
FDS
Documents