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ACROBiosystems Cynomolgus CD3 epsilon Protein, Fc,His Tag

Marque:  ACROBiosystems CDE-C5254-1MG

Informations supplémentaires : Poids : 0.00001kg

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Code produit. 15876387

  • 1997.41€ / 1mg
Date d’expédition estimée: 10-01-2022

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Description

Description

CD3e molecule, epsilon is also known as CD3E, is a T-cell surface single-pass type I membrane glycoprotein. CD3E contains 1 Ig-like (immunoglobulin-like) domain and 1 ITAM domain. CD3E, together with CD3-gamma, CD3-delta and CD3-zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. The epsilon polypeptide plays an essential role in T-cell development. CD3E plays an essential role in T-cell development, and defects in CD3E gene cause severe immunodeficiency. CD3E gene has also been linked to a susceptibility to type I diabetes in women. CD3E has been shown to interact with TOP2B, CD3EAP and NCK2.

This protein carries a human IgG1 Fc tag at the C-terminus, followed by a polyhistidine tag. The protein has a calculated MW of 38.3 kDa. The protein migrates as 43-50 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Spécification

Spécification

Less than 1.0 EU / µg by the LAL method.
Bio-Markers and CD Antigens
Powder
>95% as determined by SDS-PAGE
Cynomolgus CD3 epsilon, Fc,His Tag (CDE-C5254) is expressed from human 293 cells (HEK293). It contains AA Gln 22 - Asp 117 (Accession # Q95LI5).
-20°C
CD3 epsilon
His Tag and Fc Tag
HEK293
Cynomolgus
38.3 kDa
1 mg
Gln 22 - Asp 117
FLJ18683,T3E,TCRE,CD3E,CD3-epsilon
Unconjugated
Tris with Glycine, Arginine and NaCl, pH7.5
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