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DCP1A Rabbit anti-Human, Mouse, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Marque:  Proteintech 22373-1-AP-20UL

Informations supplémentaires : Poids : 0.00010kg

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Code produit. 16831905

  • 121.38€ / 20µL
Expédition estimée: 29-09-2022
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Description

Description

This antibody specifically react with the 70 kDa DCP1A protein.

Signal transduction of TGF-beta superfamily members is regulated by Smad proteins. In particular, Smads influence specific gene transcription by relaying signals from the cell membrane to the nucleus. Smad4 plays an essential role in TGF-beta-induced transcriptional activation wherein phosphorylated receptor-associated Smads associate with Smad4. Furthermore, SMIF (Smad4-intereacting protein) and Smad4 complex with TGF-beta and BMP4. An increase in Smad4 concentration increases the translocation of this complex to the nucleus. SMIF and Smad4 interact directly through a EVH1/WH1 domain on SMIF and a proline-rich activation domain on Smad4. Smad4 is essential to nuclear translocation of SMIF as deletion of the Smad4-interacting domain (located in the N-terminal 100 amino acids) of SMIF eliminates TGF-beta-induced nuclear translocation of SMIF. The human SMIF gene is ubiquitously expressed and encodes a protein with a relative molecular mass of 70 kDa.
Spécification

Spécification

DCP1A
Polyclonal
Unconjugated
DCP1A
DCP1A, HSA275986, mRNA decapping enzyme 1A, Nbla00360, SMAD4IP1, SMIF, Transcription factor SMIF
Rabbit
Antigen Affinity Chromatography
RUO
55802, 75901
-20°C
Liquid
Immunoprecipitation, Immunohistochemistry (Paraffin), Western Blot
0.23 mg/mL
PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Q91YD3, Q9NPI6
DCP1A
DCP1A Fusion Protein Ag18027
20 μL
Primary
Mouse, Human
Antibody
IgG
Vidéos
FDS
Documents
Certificats
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