missing translation for 'onlineSavingsMsg'
Learn More

Desmoglein 2 Monoclonal Antibody (CSTEM28), Alexa Fluor™ 488, eBioscience™, Invitrogen™

Mouse Monoclonal Antibody

Marque:  Affymetrix eBioscience 53-9159-80

Informations supplémentaires : Poids : 0.01000kg

 Afficher plus de versions de ce produit

Code produit. 16371004

Cet article est actuellement indisponible ou discontinu. Veuillez consulter la page produit pour de possible alternative dans l’onglet
Voir les produits de remplacement »


Description

Description

This monoclonal antibody CSTEM28 reacts with human desmoglein 2 (DSG2), a type 1 transmembrane protein belonging to the cadherin family. DSG2 is expressed by epithelial cells, cardiomyocytes, endothelial progenitors, and CD34+CD45dim hematopoietic stem and progenitor cells. This adhesion molecule forms cell-cell adhesion complexes called desmosomes that provide tensile strength to tissues that experience mechanical stress. Other than its role in desmosome formation, DSG2 plays a role in barrier integrity, adhesion, migration, cell apoptosis, proliferation, vasculogenic mimicry, and intracellular signaling. DSG2-expressing endothelial progenitor cells are pro-angiogenic, suggesting a role in vasculature formation. On hematopoietic stem and progenitor cells, DSG2 expression is highest on CD38-CD90+ multi-potent cells. DSG2 expression is progressively decreased as a function of differentiation, with DSG2 expression absent on mature lymphocytes. DSG2 also serves as a receptor for adenoviruses and can be shed by mucosal barriers in the intestine. This CSTEM28 antibody has been tested by flow cytometric analysis of 2102ep cell line. This has also been tested by immunocytochemistry of fixed and permeabilized cells and can be used at less than or equal to 10 μg/mL. It is recommended the antibody be carefully titrated for optimal performance in the assay of interest. Filtration: 0.2 μm post-manufacturing filtered.

Desmosomes are cell-cell junctions between epithelial, myocardial, and certain other cell types. Currently, three desmoglein subfamily members have been identified and all are members of the cadherin cell adhesion molecule superfamily. These desmoglein gene family members are located in a cluster on chromosome 18. This protein has been identified as the autoantigen of the autoimmune skin blistering disease pemphigus vulgaris.
Spécification

Spécification

Desmoglein 2
Monoclonal
0.5 mg/mL
PBS with 0.1% gelatin and 0.09% sodium azide
Q14126
DSG2
Affinity chromatography
RUO
1829
4° C, store in dark, DO NOT FREEZE!
Liquid
Flow Cytometry, Immunocytochemistry
CSTEM28
Alexa Fluor 488
DSG2
Desmoglein-2; DSG-2; DSG2; ARVC10; ARVD10; CDHF5; CMD1BB; HDGC
Mouse
25 μg
Primary
Human
Antibody
IgG2b κ
Suggestions de produits

Suggestions de produits

Vidéos
FDS
Documents

Documents

Certificats
Promotions

Promotions

For Research Use Only.