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FOXP3 Monoclonal Antibody (FJK-16s), APC, eBioscience™, Invitrogen™

Rat Monoclonal Antibody

Marque:  Affymetrix eBioscience 17-5773-80

290.70 EUR valable jusqu'au 2024-03-29
Utilisez le code promo "21653" pour bénéficier de cette offre.



Code nomenclature Nacres: NA.41

Informations supplémentaires : Poids : 0.25000kg

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Code produit. 15330750

  • 306.00€ / 25µg
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Description

Description

Description: The FJK-16s antibody reacts with mouse, rat, dog, porcine, bovine and cat Foxp3 also known as FORKHEAD BOX P3, SCURFIN, and JM2; cross reactivity of this antibody to other proteins has not been determined. Foxp3, a 49-55 kDa protein, is a member of the forkhead/winged-helix family of transcriptional regulators, and was identified as the gene defective in 'scurfy' (sf) mice. Constitutive high expression of foxP3 mRNA has been shown in CD4+CD25+ regulatory T cells (Treg cells), and ectopic expression of foxp3 in CD4+CD25- cells imparts a Treg phenotype in these cells. Immunoblotting with FJK-16s antibody has mapped the epitope to amino acids 75-125 of the mouse Foxp3 protein. In the human, this region has been shown to be alternatively spliced at the mRNA level. Both the alternatively-spliced and non-spliced isoforms are present in the CD4+CD25+ subset of lymphocytes. Preliminary RT-PCR experiments have not revealed this alternatively-spliced isoform in mouse splenocytes, suggesting different gene regulation in the mouse and human. Please note that FJK-16s has been optimized for use with the Foxp3/Transcription Factor Buffer Staining Set (cat. 00-5523). The use of other fixation and staining buffers is not recommended. Applications Reported: This FJK-16s antibody has been reported for use in intracellular staining followed by flow cytometric analysis.

FOXP3 Monoclonal antibody specifically detects FOXP3 in Bovine, Canine, Feline, Mouse, Porcine, Rat samples. It is validated for Flow Cytometry.
Spécification

Spécification

FOXP3
Monoclonal
0.2 mg/mL
PBS with 0.09% sodium azide; pH 7.2
Q99JB6
Foxp3
Affinity chromatography
RUO
100037405, 20371, 317382, 444998, 491876, 506053
4° C, store in dark, DO NOT FREEZE!
Liquid
Flow Cytometry
FJK-16s
APC
Foxp3
AIID; DIETER; forkhead box P3; forkhead box protein P3; Forkhead box protein P3 41 kDa form; Forkhead box protein P3, C-terminally processed; forkhead/winged helix transcription factor 3; Foxp3; FOXP3delta7; immune dysregulation, polyendocrinopathy, enteropathy, X-linked; immunodeficiency, polyendocrinopathy, enteropathy, X-linked; IPEX; JM2; MGC141961; MGC141963; PIDX; regulatory protein Foxp3; RGD1562112; RP23-54C14.1; scurfin; scurfy; sf; XPID
Rat
25 μg
Primary
Bovine, Canine, Feline, Mouse, Porcine, Rat
Antibody
IgG2a κ
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For Research Use Only.