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ACROBiosystems Human Akt1 Protein, His,Strep II Tag

419.88€ - 1943.45€

Spécification

Numéro d’adhésion AAH00479
Poids moléculaire 59.5 kDa
Source Human Akt1, His,Strep II Tag (AK1-H5283) is expressed from human 293 cells (HEK293). It contains AA Met 1 - Ala 480 (Accession # AAH00479).
Immunogène Met 1 - Ala 480
Conditions de stockage -20°C
Consulter d'autres spécifications

Produits 2
Code produit Marque Quantité Prix Quantité et disponibilité  
Code produit Marque Quantité Prix Quantité et disponibilité  
15865897
Afficher les documents Détails de la promotion
ACROBiosystems
AK1-H5283-25UG
25 μg
419.88€
25µg
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Expédition estimée: 11-04-2024
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15875897
Afficher les documents Détails de la promotion
ACROBiosystems
AK1-H5283-500UG
500 μg
1943.45€
500µg
Voir les produits de remplacement
Économisez jusqu'à 
»
Expédition estimée: 11-04-2024
pour voir le stock disponible 
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Description

Description

RAC-alpha serine/threonine-protein kinase (AKT1) is also known PKB, Protein kinase B alpha, PKB alpha, Proto-oncogene c-Akt and RAC-PK-alpha, which belongs to the protein kinase superfamily, AGC Ser/Thr protein kinase family and RAC subfamily and is expressed in prostate cancer and levels increase from the normal to the malignant state (at protein level). AKT1 is one of 3 closely related serine/threonine-protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. AKT is responsible of the regulation of glucose uptake by mediating insulin-induced translocation of the SLC2A4/GLUT4 glucose transporter to the cell surface. AKT regulates also the storage of glucose in the form of glycogen by phosphorylating GSK3A at 'Ser-21' and GSK3B at 'Ser-9', resulting in inhibition of its kinase activity. Phosphorylation of GSK3 isoforms by AKT is also thought to be one mechanism by which cell proliferation is driven. AKT regulates also cell survival via the phosphorylation of MAP3K5 (apoptosis signal-related kinase).

This protein carries a polyhistidine tag at the C-terminus, followed by a twin strep tag. The protein has a calculated MW of 59.5 kDa. The protein migrates as 60-66 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Spécification

Spécification

AAH00479
Human Akt1, His,Strep II Tag (AK1-H5283) is expressed from human 293 cells (HEK293). It contains AA Met 1 - Ala 480 (Accession # AAH00479).
-20°C
Akt1
Human
20 mM Tris, 150 mM NaCl, pH8.0
HEK293
Other Recombinant Proteins
59.5 kDa
Met 1 - Ala 480
AKT1,PKB,RAC,RAC-Pk.-alpha,PKB alpha
Unconjugated
His Tag and Strep Tag
Less than 1.0 EU / μg by the LAL method.
Powder
>92% as determined by reduced SDS-PAGE
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FDS
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