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ACROBiosystems Human Angiopoietin-like 3 / ANGPTL3 Protein, His Tag

Marque:  ACROBiosystems AN3-H5226-1MG

Informations supplémentaires : Poids : 0.00001kg

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Code produit. 15875907

  • 1815.83€ / 1mg
Date d’expédition estimée: 28-12-2021

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Description

Description

Angiopoietin-like protein 3 (ANGPTL3) is also known as Angiopoietin-related protein 3, Angiopoietin-5 (ANGPT5 / ANG-5), is a member of the angiopoietin-like family of secreted factors. ANGPTL3 / ANGPT5 is predominantly expressed in the liver, and has the characteristic structure of angiopoietins, consisting of a signal peptide, N-terminal coiled-coil domain and the C-terminal fibrinogen (FBN)-like domain. The FBN-like domain in angiopoietin-like 3 protein was shown to bind alpha-5/beta-3 integrins, and this binding induced endothelial cell adhesion and migration. This protein may also play a role in the regulation of angiogenesis. Angptl3 also acts as dual inhibitor of lipoprotein lipase (LPL) and endothelial lipase (EL), and increases plasma triglyceride and HDL cholesterol in rodents. ANGPTL3 inhibit endothelial lipase to catalyze HDL-phospholipid and increase HDL-PL levels. Circulating PL-riched HDL particles have high cholesterol efflux abilities.

This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 24.6 kDa. The protein migrates as 26-38 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Spécification

Spécification

NP_055310
HEK293
Human
24.6 kDa
1 mg
Ser 17 - Pro 220
ANGPTL3,ANGPT5,ANG-5,Angiopoietin-5,FHBL2
Unconjugated
PBS, pH7.4
Less than 1.0 EU / µg by the LAL method.
Cytokines and Growth Factors
Powder
>95% as determined by reduced SDS-PAGE
Human Angiopoietin-like 3, His Tag (AN3-H5226) is expressed from human 293 cells (HEK293). It contains AA Ser 17 - Pro 220 (Accession # NP_055310).
-20°C
Angiopoietin-like 3
His Tag
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