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ACROBiosystems Human CD46 Protein, His Tag

Marque:  ACROBiosystems CD6-H5226-50UG

Informations supplémentaires : Poids : 0.00001kg

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Code produit. 15856227

  • 383.89€ / 50µg
Expédition estimée: 13-02-2023
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Description

Description

Complement regulatory protein CD46 is also known as membrane Cofactor Protein (MCP), is a type I membrane protein and is a regulatory part of the complement system. CD46 is expressed by all cells except erythrocytes. MCP acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue, and also acts as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells. In T-cells by binding to CD46, A number of viral and bacterial pathogens seem to exploit this property and directly induce an immunosuppressive phenotype. Defects in CD46 are a cause of susceptibility to hemolytic uremic syndrome atypical type 2 (AHUS2).

This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 33.6 kDa. The protein migrates as 45-60 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Spécification

Spécification

AAH30594.1
33.6 kDa
50 µg
Cys 35 - Asp 328
CD46,AHUS2,MCP,MIC10,TLX,TRA2.10
Unconjugated
PBS, pH7.4
HEK293
Human
Powder
>90% as determined by SDS-PAGE
Human CD46, His Tag (CD6-H5226) is expressed from human 293 cells (HEK293). It contains AA Cys 35 - Asp 328 (Accession # AAH30594.1).
-20°C
CD46
His Tag
Less than 1.0 EU / µg by the LAL method.
Bio-Markers and CD Antigens
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