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ACROBiosystems Human CD46 Protein, His Tag
Marque: ACROBiosystems CD6-H5226-50UG
Informations supplémentaires : Poids : 0.00001kg
Description
Complement regulatory protein CD46 is also known as membrane Cofactor Protein (MCP), is a type I membrane protein and is a regulatory part of the complement system. CD46 is expressed by all cells except erythrocytes. MCP acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue, and also acts as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells. In T-cells by binding to CD46, A number of viral and bacterial pathogens seem to exploit this property and directly induce an immunosuppressive phenotype. Defects in CD46 are a cause of susceptibility to hemolytic uremic syndrome atypical type 2 (AHUS2).
This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 33.6 kDa. The protein migrates as 45-60 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.Spécification
| AAH30594.1 | |
| 50 μg | |
| Cys 35 - Asp 328 | |
| CD46,AHUS2,MCP,MIC10,TLX,TRA2.10 | |
| Unconjugated | |
| His Tag | |
| Less than 1.0 EU / μg by the LAL method. | |
| Powder | |
| >90% as determined by SDS-PAGE |
| 33.6 kDa | |
| Human CD46, His Tag (CD6-H5226) is expressed from human 293 cells (HEK293). It contains AA Cys 35 - Asp 328 (Accession # AAH30594.1). | |
| -20°C | |
| CD46 | |
| Human | |
| PBS, pH7.4 | |
| HEK293 | |
| Bio-Markers and CD Antigens |