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ACROBiosystems Human FAP Protein, His Tag (active enzyme)
MALS verified
362.89€ - 3471.71€
Spécification
| Poids moléculaire | 86.9 kDa |
|---|---|
| Source | Human FAP, His Tag (MALS verified) (FAP-H5244) is expressed from human 293 cells (HEK293). It contains AA Leu 26 - Asp 760 (Accession # Q12884-1). |
| Immunogène | Leu 26 - Asp 760 |
| Conditions de stockage | -20°C |
| Alias de gène | FAP,FAPalpha,SIMP,Seprase,APCE |
| Code produit | Marque | Quantité | Prix | Quantité et disponibilité | |||||
|---|---|---|---|---|---|---|---|---|---|
| Code produit | Marque | Quantité | Prix | Quantité et disponibilité | |||||
|
16618522
|
ACROBiosystems
FAP-H5244-100UG |
100 μg |
1052.40€
100µg |
Expédition estimée: 07-05-2024 Connectez-vous pour voir le stock disponible |
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|
17126291
|
ACROBiosystems
FAP-H5244-20UG |
20 μg |
362.89€
20µg |
Expédition estimée: 07-05-2024 Connectez-vous pour voir le stock disponible |
Veuillez vous connecter pour pouvoir commander cet article. Besoin d'un compte web? Créer le vôtre dès maintenant! | ||||
|
17136291
|
ACROBiosystems
FAP-H5244-500UG |
500 μg |
3471.71€
500µg |
Expédition estimée: 07-05-2024 Connectez-vous pour voir le stock disponible |
Veuillez vous connecter pour pouvoir commander cet article. Besoin d'un compte web? Créer le vôtre dès maintenant! | ||||
Description
FAP (also known as seprase) is a Type II transmembrane serine protease. Both plasma membrane and soluble forms exhibit post-proline cleaving endopeptidase activity, with a marked preference for Ala/Ser-Gly-Pro-Ser/Asn/Ala consensus sequences. Degrade also gelatin, heat-denatured type I collagen. Also has dipeptidyl peptidase activity, with a preference for Ala-Pro, Ile-Pro, Gly-Pro, Arg-Pro and Pro-Pro. The plasma membrane form, in association with either DPP4, PLAUR or integrins, is involved in the pericellular proteolysis of the extracellular matrix (ECM), and hence promotes cell adhesion, migration and invasion through the ECM. Promotes glioma cell invasion through the brain parenchyma by degrading the proteoglycan brevican. Acts as a tumor suppressor in melanocytic cells through regulation of cell proliferation and survival in a serine protease activity-independent manner.
This protein carries a polyhistidine tag at the N-terminus. The protein has a calculated MW of 86.9 kDa. The protein migrates as 95 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.Spécification
| 86.9 kDa | |
| Leu 26 - Asp 760 | |
| FAP,FAPalpha,SIMP,Seprase,APCE | |
| Unconjugated | |
| His Tag | |
| Less than 1.0 EU / μg by the LAL method. | |
| Powder | |
| >95% as determined by SDS-PAGE |
| Human FAP, His Tag (MALS verified) (FAP-H5244) is expressed from human 293 cells (HEK293). It contains AA Leu 26 - Asp 760 (Accession # Q12884-1). | |
| -20°C | |
| FAP | |
| Human | |
| PBS, pH7.4 | |
| HEK293 | |
| Enzymes |